IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0071640.html
   My bibliography  Save this article

GSTP1 Ile105Val Polymorphism and Prostate Cancer Risk: Evidence from a Meta-Analysis

Author

Listed:
  • Bingbing Wei
  • You Zhou
  • Zhuoqun Xu
  • Jun Ruan
  • Huan Cheng
  • Ming Zhu
  • Qiang Hu
  • Ke Jin
  • Zhiqiang Yan
  • Deqi Zhou
  • Feng Xuan
  • Hongyi Zhou
  • Zhirong Wang
  • Xing Huang
  • Qiang Wang

Abstract

Background: Glutathione S-transferase P1 (GSTP1) is thought to be involved in the detoxification of reactive carcinogen metabolites. Numerous epidemiological studies have evaluated the association of GSTP1 Ile105Val polymorphism with the risk of prostate cancer. However, the results remain inconclusive. To derive a more precise estimation, a meta-analysis was performed. Methodology/Principal Findings: A comprehensive search was conducted to identify the eligible studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the relationship. The overall association was not significant (Val/Val vs. Ile/Ile OR = 1.06, 95% CI = 0.90–1.25, P = 0.50; Val/Val vs. Val/Ile+Ile/Ile: OR = 1.07, 95% CI = 0.91–1.25, P = 0.44). In subgroup analyses by ethnicity and prostate cancer grade, the similar results were observed. However, in stratified analysis by clinical stage, we found a significant association with low-stage prostate cancer (Val/Val vs. Ile/Ile: OR = 2.70, 95% CI = 1.73–4.22, P

Suggested Citation

  • Bingbing Wei & You Zhou & Zhuoqun Xu & Jun Ruan & Huan Cheng & Ming Zhu & Qiang Hu & Ke Jin & Zhiqiang Yan & Deqi Zhou & Feng Xuan & Hongyi Zhou & Zhirong Wang & Xing Huang & Qiang Wang, 2013. "GSTP1 Ile105Val Polymorphism and Prostate Cancer Risk: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
    • Handle: RePEc:plo:pone00:0071640
    DOI: 10.1371/journal.pone.0071640
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071640
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0071640&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0071640?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mohammad H. Rahbar & Maureen Samms-Vaughan & Jianzhong Ma & Jan Bressler & Katherine A. Loveland & Manouchehr Ardjomand-Hessabi & Aisha S. Dickerson & Megan L. Grove & Sydonnie Shakespeare-Pellington , 2014. "Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 11(8), pages 1-22, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0071640. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.