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A core gut microbiome in obese and lean twins

Author

Listed:
  • Peter J. Turnbaugh

    (Center for Genome Sciences)

  • Micah Hamady

    (Department of Computer Science)

  • Tanya Yatsunenko

    (Center for Genome Sciences)

  • Brandi L. Cantarel

    (CNRS, UMR6098, Marseille, France)

  • Alexis Duncan

    (Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Ruth E. Ley

    (Center for Genome Sciences)

  • Mitchell L. Sogin

    (Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA)

  • William J. Jones

    (Environmental Genomics Core Facility, University of South Carolina, Columbia, South Carolina 29208, USA)

  • Bruce A. Roe

    (University of Oklahoma, Norman, Oklahoma 73019, USA)

  • Jason P. Affourtit

    (454 Life Sciences, Branford, Connecticut 06405, USA)

  • Michael Egholm

    (454 Life Sciences, Branford, Connecticut 06405, USA)

  • Bernard Henrissat

    (CNRS, UMR6098, Marseille, France)

  • Andrew C. Heath

    (Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Rob Knight

    (University of Colorado, Boulder, Colorado 80309, USA)

  • Jeffrey I. Gordon

    (Center for Genome Sciences)

Abstract

Obese and lean microbiota The many 'friendly' microbes that inhabit the human gut have been implicated in numerous health-related issues, in particular those involving digestion and susceptibility to infection. A study of the faecal microbial communities of pairs of adult female twins, selected to include 'lean' and 'obese' individuals, reveals some similarities between the human gut microbiomes among family members, but each person's gut microbial community varies in the specific bacterial lineages present. There was a wide array of shared microbial genes among individuals, comprising an identifiable 'core microbiome' at the gene, rather than at the microbial species level. This core includes many novel genes for carbohydrate metabolism, and deviations from this core are associated with the obese versus lean state.

Suggested Citation

  • Peter J. Turnbaugh & Micah Hamady & Tanya Yatsunenko & Brandi L. Cantarel & Alexis Duncan & Ruth E. Ley & Mitchell L. Sogin & William J. Jones & Bruce A. Roe & Jason P. Affourtit & Michael Egholm & Be, 2009. "A core gut microbiome in obese and lean twins," Nature, Nature, vol. 457(7228), pages 480-484, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07540
    DOI: 10.1038/nature07540
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