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The Potential of Novel Gene Editing-Based Approaches in Forages and Rumen Archaea for Reducing Livestock Methane Emissions

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  • Udaya Subedi

    (Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB T1J 4B1, Canada
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada)

  • Kazi Kader

    (Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB T1J 4B1, Canada)

  • Kethmi N. Jayawardhane

    (Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada)

  • Hari Poudel

    (Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB T1J 4B1, Canada)

  • Guanqun Chen

    (Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada)

  • Surya Acharya

    (Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB T1J 4B1, Canada)

  • Luiz S. A. Camargo

    (Embrapa Dairy Cattle, Juiz de Fora 36038-330, MG, Brazil)

  • Daniela Matias de C. Bittencourt

    (Embrapa Genetic Resources and Biotechnology, Brasília 70770-917, DF, Brazil)

  • Stacy D. Singer

    (Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB T1J 4B1, Canada)

Abstract

Rising emissions of anthropogenic greenhouse gases such as carbon dioxide (CO 2 ), nitrous oxide (N 2 O) and methane (CH 4 ) are a key driver of climate change, which is predicted to have myriad detrimental consequences in coming years if not kept in check. Given the potency of CH 4 in terms of trapping heat in the atmosphere in the short term, as well as the fact that ruminant production currently contributes approximately 30% of anthropogenic emissions, there is an impetus to substantially decrease the generation of ruminant-derived CH 4 . While various strategies are being assessed in this context, a multi-faceted approach is likely required to achieve significant reductions. Feed supplementation is one strategy that has shown promise in this field by attenuating methanogenesis in rumen archaea; however, this can be costly and sometimes impractical. In this review, we examine and discuss the prospect of directly modulating forages and/or rumen archaea themselves in a manner that would reduce methanogenesis using CRISPR/Cas-mediated gene editing platforms. Such an approach could provide a valuable alternative to supplementation and has the potential to contribute to the sustainability of agriculture, as well as the mitigation of climate change, in the future.

Suggested Citation

  • Udaya Subedi & Kazi Kader & Kethmi N. Jayawardhane & Hari Poudel & Guanqun Chen & Surya Acharya & Luiz S. A. Camargo & Daniela Matias de C. Bittencourt & Stacy D. Singer, 2022. "The Potential of Novel Gene Editing-Based Approaches in Forages and Rumen Archaea for Reducing Livestock Methane Emissions," Agriculture, MDPI, vol. 12(11), pages 1-21, October.
  • Handle: RePEc:gam:jagris:v:12:y:2022:i:11:p:1780-:d:954069
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    References listed on IDEAS

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