IDEAS home Printed from https://ideas.repec.org/a/eee/thpobi/v82y2012i3p209-221.html
   My bibliography  Save this article

Epistasis can increase multivariate trait diversity in haploid non-recombining populations

Author

Listed:
  • Griswold, Cortland K.
  • Henry, Thomas A.

Abstract

We evaluate the effect of epistasis on genetically-based multivariate trait variation in haploid non-recombining populations. In a univariate setting, past work has shown that epistasis reduces genetic variance (additive plus epistatic) in a population experiencing stabilizing selection. Here we show that in a multivariate setting, epistasis also reduces total genetic variation across the entire multivariate trait in a population experiencing stabilizing selection. But, we also show that the pattern of variation across the multivariate trait can be more even when epistasis occurs compared to when epistasis is absent, such that some character combinations will have more genetic variance when epistasis occurs compared to when epistasis is absent. In fact, a measure of generalized multivariate trait variation can be increased by epistasis under weak to moderate stabilizing selection conditions, as well as neutral conditions. Likewise, a measure of conditional evolvability can be increased by epistasis under weak to moderate stabilizing selection and neutral conditions. We investigate the nature of epistasis assuming a multivariate-normal model genetic effects and investigate the nature of epistasis underlying the biophysical properties of RNA. Increased multivariate diversity occurs for populations that are infinite in size, as well as populations that are finite in size. Our model of finite populations is explicitly genealogical and we link our findings about the evenness of eigenvalues with epistasis to prior work on the genealogical mapping of epistatic effects.

Suggested Citation

  • Griswold, Cortland K. & Henry, Thomas A., 2012. "Epistasis can increase multivariate trait diversity in haploid non-recombining populations," Theoretical Population Biology, Elsevier, vol. 82(3), pages 209-221.
    • Handle: RePEc:eee:thpobi:v:82:y:2012:i:3:p:209-221
    DOI: 10.1016/j.tpb.2012.06.007
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S004058091200069X
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.tpb.2012.06.007?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Griswold, Cortland K. & Eisner, Danielle J., 2012. "The mapping of epistatic effects onto a genealogical tree in haploid populations," Theoretical Population Biology, Elsevier, vol. 81(1), pages 32-44.
    2. Paul B. Rainey & Michael Travisano, 1998. "Adaptive radiation in a heterogeneous environment," Nature, Nature, vol. 394(6688), pages 69-72, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Anna Y. Alekseeva & Anneloes E. Groenenboom & Eddy J. Smid & Sijmen E. Schoustra, 2021. "Eco-Evolutionary Dynamics in Microbial Communities from Spontaneous Fermented Foods," IJERPH, MDPI, vol. 18(19), pages 1-19, September.
    2. Ryo Mizuuchi & Taro Furubayashi & Norikazu Ichihashi, 2022. "Evolutionary transition from a single RNA replicator to a multiple replicator network," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Nicholas Leiby & Christopher J Marx, 2014. "Metabolic Erosion Primarily Through Mutation Accumulation, and Not Tradeoffs, Drives Limited Evolution of Substrate Specificity in Escherichia coli," PLOS Biology, Public Library of Science, vol. 12(2), pages 1-10, February.
    4. M. Doebeli & U. Dieckmann, 2000. "Evolutionary Branching and Sympatric Speciation Caused by Different Types of Ecological Interactions," Working Papers ir00040, International Institute for Applied Systems Analysis.
    5. Kyle A Young & Jos Snoeks & Ole Seehausen, 2009. "Morphological Diversity and the Roles of Contingency, Chance and Determinism in African Cichlid Radiations," PLOS ONE, Public Library of Science, vol. 4(3), pages 1-8, March.
    6. N. Frazão & A. Konrad & M. Amicone & E. Seixas & D. Güleresi & M. Lässig & I. Gordo, 2022. "Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Safar Vafadar & Maryam Shahdoust & Ata Kalirad & Pooya Zakeri & Mehdi Sadeghi, 2021. "Competitive exclusion during co-infection as a strategy to prevent the spread of a virus: A computational perspective," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-18, February.
    8. Amandine Nucci & Eduardo P. C. Rocha & Olaya Rendueles, 2022. "Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:thpobi:v:82:y:2012:i:3:p:209-221. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: https://www.journals.elsevier.com/intelligence .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.