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Evolutionary transition from a single RNA replicator to a multiple replicator network

Author

Listed:
  • Ryo Mizuuchi

    (The University of Tokyo
    JST, PRESTO)

  • Taro Furubayashi

    (The University of Tokyo)

  • Norikazu Ichihashi

    (The University of Tokyo
    The University of Tokyo
    The University of Tokyo)

Abstract

In prebiotic evolution, self-replicating molecules are believed to have evolved into complex living systems by expanding their information and functions open-endedly. Theoretically, such evolutionary complexification could occur through successive appearance of novel replicators that interact with one another to form replication networks. Here we perform long-term evolution experiments of RNA that replicates using a self-encoded RNA replicase. The RNA diversifies into multiple coexisting host and parasite lineages, whose frequencies in the population initially fluctuate and gradually stabilize. The final population, comprising five RNA lineages, forms a replicator network with diverse interactions, including cooperation to help the replication of all other members. These results support the capability of molecular replicators to spontaneously develop complexity through Darwinian evolution, a critical step for the emergence of life.

Suggested Citation

  • Ryo Mizuuchi & Taro Furubayashi & Norikazu Ichihashi, 2022. "Evolutionary transition from a single RNA replicator to a multiple replicator network," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29113-x
    DOI: 10.1038/s41467-022-29113-x
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    References listed on IDEAS

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