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Viral diversity limits immune diversity in asymptomatic phase of HIV infection

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  • Iwami, Shingo
  • Nakaoka, Shinji
  • Takeuchi, Yasuhiro

Abstract

We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number “immune diversity threshold†. Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.

Suggested Citation

  • Iwami, Shingo & Nakaoka, Shinji & Takeuchi, Yasuhiro, 2008. "Viral diversity limits immune diversity in asymptomatic phase of HIV infection," Theoretical Population Biology, Elsevier, vol. 73(3), pages 332-341.
    • Handle: RePEc:eee:thpobi:v:73:y:2008:i:3:p:332-341
    DOI: 10.1016/j.tpb.2008.01.003
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    References listed on IDEAS

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    1. Andrew J. McMichael & Sarah L. Rowland-Jones, 2001. "Cellular immune responses to HIV," Nature, Nature, vol. 410(6831), pages 980-987, April.
    2. Daniel L. Barber & E. John Wherry & David Masopust & Baogong Zhu & James P. Allison & Arlene H. Sharpe & Gordon J. Freeman & Rafi Ahmed, 2006. "Restoring function in exhausted CD8 T cells during chronic viral infection," Nature, Nature, vol. 439(7077), pages 682-687, February.
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    Cited by:

    1. Gao, Ting & Wang, Wendi & Liu, Xianning, 2011. "Mathematical analysis of an HIV model with impulsive antiretroviral drug doses," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 82(4), pages 653-665.

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