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Occupational Low-Dose Radiation Affects the Expression of Immune Checkpoint of Medical Radiologists

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  • Chen Wang

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Changfu Hao

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Kai Dai

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Yuzheng Li

    (Henan Institute of Occupational Medicine, Zhengzhou 450001, China)

  • Jie Jiao

    (Henan Institute of Occupational Medicine, Zhengzhou 450001, China)

  • Zhuoya Niu

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Xiao Xu

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Xuedan Deng

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Jing He

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Wu Yao

    (Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

Abstract

The purpose of this study was to investigate the expression of immune checkpoint cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T cell immunoglobulin and mucin domain 3 (TIM-3) in the peripheral blood T lymphocytes of medical radiologists. The study incorporated 100 male medical radiologists and 107 male healthy controls. The expressions of CTLA-4 and TIM-3 among CD4+ and CD8+ lymphocytes were detected by flow cytometry. The expression levels of CTLA-4 and TIM-3 in the CD4+T cells of radiation workers were lower than those of healthy controls ( p < 0.05). Correlation analysis showed that the CD8+CTLA-4 expression level was significantly positively correlated with individual cumulative dose ( r s = 0.260, p = 0.001, <0.05), while the expression level of CD8+TIM-3 was negatively correlated ( r s = −0.180, p = 0.027, <0.05). Low-dose radiation exposure affects the expression of CTLA-4 and TIM-3 in human peripheral blood T lymphocytes. Future studies need to focus on exploring the mechanisms by which CTLA-4 and TIM-3 expression changes in response to low-dose radiation exposure.

Suggested Citation

  • Chen Wang & Changfu Hao & Kai Dai & Yuzheng Li & Jie Jiao & Zhuoya Niu & Xiao Xu & Xuedan Deng & Jing He & Wu Yao, 2022. "Occupational Low-Dose Radiation Affects the Expression of Immune Checkpoint of Medical Radiologists," IJERPH, MDPI, vol. 19(12), pages 1-14, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7105-:d:835298
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    References listed on IDEAS

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    1. Daniel L. Barber & E. John Wherry & David Masopust & Baogong Zhu & James P. Allison & Arlene H. Sharpe & Gordon J. Freeman & Rafi Ahmed, 2006. "Restoring function in exhausted CD8 T cells during chronic viral infection," Nature, Nature, vol. 439(7077), pages 682-687, February.
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