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Cellular immune responses to HIV

Author

Listed:
  • Andrew J. McMichael

    (MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital)

  • Sarah L. Rowland-Jones

    (MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital)

Abstract

The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

Suggested Citation

  • Andrew J. McMichael & Sarah L. Rowland-Jones, 2001. "Cellular immune responses to HIV," Nature, Nature, vol. 410(6831), pages 980-987, April.
    • Handle: RePEc:nat:nature:v:410:y:2001:i:6831:d:10.1038_35073658
    DOI: 10.1038/35073658
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    Cited by:

    1. Jonathan M Carlson & Zabrina L Brumme & Christine M Rousseau & Chanson J Brumme & Philippa Matthews & Carl Kadie & James I Mullins & Bruce D Walker & P Richard Harrigan & Philip J R Goulder & David He, 2008. "Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag," PLOS Computational Biology, Public Library of Science, vol. 4(11), pages 1-23, November.
    2. Iwami, Shingo & Nakaoka, Shinji & Takeuchi, Yasuhiro, 2008. "Viral diversity limits immune diversity in asymptomatic phase of HIV infection," Theoretical Population Biology, Elsevier, vol. 73(3), pages 332-341.
    3. Nadia Anikeeva & Maria Steblyanko & Leticia Kuri-Cervantes & Marcus Buggert & Michael R. Betts & Yuri Sykulev, 2022. "The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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