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The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Author

Listed:
  • Nadia Anikeeva

    (Thomas Jefferson University)

  • Maria Steblyanko

    (Thomas Jefferson University)

  • Leticia Kuri-Cervantes

    (Perelman School of Medicine, University of Pennsylvania)

  • Marcus Buggert

    (Perelman School of Medicine, University of Pennsylvania
    Karolinska Institutet, Karolinska University Hospital Huddinge)

  • Michael R. Betts

    (Perelman School of Medicine, University of Pennsylvania)

  • Yuri Sykulev

    (Thomas Jefferson University
    Thomas Jefferson University)

Abstract

Chronic HIV infection causes persistent low-grade inflammation that induces premature aging of the immune system including senescence of memory and effector CD8 T cells. To uncover the reasons of gradually diminished potency of CD8 T cells from people living with HIV, here we expose the T cells to planar lipid bilayers containing ligands for T-cell receptor and a T-cell integrins and analyze the cellular morphology, dynamics of synaptic interface formation and patterns of the cellular degranulation. We find a large fraction of phenotypically naive T cells from chronically infected people are capable to form mature synapse with focused degranulation, a signature of a differentiated T cells. Further, differentiation of aberrant naive T cells may lead to the development of anomalous effector T cells undermining their capacity to control HIV and other pathogens that could be contained otherwise.

Suggested Citation

  • Nadia Anikeeva & Maria Steblyanko & Leticia Kuri-Cervantes & Marcus Buggert & Michael R. Betts & Yuri Sykulev, 2022. "The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34157-0
    DOI: 10.1038/s41467-022-34157-0
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    References listed on IDEAS

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    1. Andrew J. McMichael & Sarah L. Rowland-Jones, 2001. "Cellular immune responses to HIV," Nature, Nature, vol. 410(6831), pages 980-987, April.
    2. Julia Drylewicz & Nienke Vrisekoop & Tendai Mugwagwa & Anne Bregje de Boer & Sigrid A Otto & Mette D Hazenberg & Kiki Tesselaar & Rob J de Boer & José A M Borghans, 2016. "Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-12, March.
    3. Colin R. F. Monks & Benjamin A. Freiberg & Hannah Kupfer & Noah Sciaky & Abraham Kupfer, 1998. "Three-dimensional segregation of supramolecular activation clusters in T cells," Nature, Nature, vol. 395(6697), pages 82-86, September.
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