IDEAS home Printed from https://ideas.repec.org/a/eee/socmed/v324y2023ics0277953623001466.html
   My bibliography  Save this article

Organizing precision medicine: A case study of Memorial Sloan Kettering Cancer Center's engagement in/with genomics

Author

Listed:
  • Polk, Jess B.
  • Campbell, Jonah
  • Drilon, Alexander E.
  • Keating, Peter
  • Cambrosio, Alberto

Abstract

Recent decades have seen a dramatic rise of in the number of initiatives designed to promote precision oncology, a domain that has played a pioneering role in the implementation of post-genomic approaches and technologies such as innovative clinical trial designs and molecular profiling. In this paper, based on fieldwork carried out at the Memorial Sloan-Kettering Cancer Center from 2019 onwards, we analyze how a world-leading cancer center has adapted, responded, and contributed to the challenge of “doing” precision oncology by developing new programs and services, and building an infrastructure that has created the conditions for genomic practices. We do so by attending to the “organizing” side of precision oncology and to the nexus between these activities and epistemic issues. We situate the work that goes into making results actionable and accessing targeted drugs within the larger process of creating a precision medicine ecosystem that includes purpose-built institutional settings, thus simultaneously experimenting with bioclinical matters and, reflexively, with organizing practices. The constitution and articulation of innovative sociotechnical arrangements at MSK provides a unique case study of the production of a large and complex clinical research ecosystem designed to implement rapidly evolving therapeutic strategies embedded in a renewed and dynamic understanding of cancer biology.

Suggested Citation

  • Polk, Jess B. & Campbell, Jonah & Drilon, Alexander E. & Keating, Peter & Cambrosio, Alberto, 2023. "Organizing precision medicine: A case study of Memorial Sloan Kettering Cancer Center's engagement in/with genomics," Social Science & Medicine, Elsevier, vol. 324(C).
    • Handle: RePEc:eee:socmed:v:324:y:2023:i:c:s0277953623001466
    DOI: 10.1016/j.socscimed.2023.115789
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0277953623001466
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.socscimed.2023.115789?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Tempini, Niccolò & Leonelli, Sabina, 2021. "Actionable data for precision oncology: Framing trustworthy evidence for exploratory research and clinical diagnostics," Social Science & Medicine, Elsevier, vol. 272(C).
    2. Samer Faraj & Lee Sproull, 2000. "Coordinating Expertise in Software Development Teams," Management Science, INFORMS, vol. 46(12), pages 1554-1568, December.
    3. Nelson, Nicole C. & Keating, Peter & Cambrosio, Alberto & Aguilar-Mahecha, Adriana & Basik, Mark, 2014. "Testing devices or experimental systems? Cancer clinical trials take the genomic turn," Social Science & Medicine, Elsevier, vol. 111(C), pages 74-83.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cambrosio, Alberto & Campbell, Jonah & Keating, Peter & Polk, Jessica B. & Aguilar-Mahecha, Adriana & Basik, Mark, 2022. "Healthcare policy by other means: Cancer clinical research as “oncopolicy”," Social Science & Medicine, Elsevier, vol. 292(C).
    2. Henrik Bresman, 2010. "External Learning Activities and Team Performance: A Multimethod Field Study," Organization Science, INFORMS, vol. 21(1), pages 81-96, February.
    3. Bai, Yuntao & Lin, Li & Li, Peter Ping, 2016. "How to enable employee creativity in a team context: A cross-level mediating process of transformational leadership," Journal of Business Research, Elsevier, vol. 69(9), pages 3240-3250.
    4. Edoardo Mollona & Andrea Marcozzi, 2009. "FirmNet: the scope of firms and the allocation of task in a knowledge-based economy," Computational and Mathematical Organization Theory, Springer, vol. 15(2), pages 109-126, June.
    5. Edoardo Mollona & Andrea Marcozzi, 2009. "Self-emerging coordination mechanisms for knowledge integration processes," Mind & Society: Cognitive Studies in Economics and Social Sciences, Springer;Fondazione Rosselli, vol. 8(2), pages 223-241, December.
    6. Kyle Lewis, 2004. "Knowledge and Performance in Knowledge-Worker Teams: A Longitudinal Study of Transactive Memory Systems," Management Science, INFORMS, vol. 50(11), pages 1519-1533, November.
    7. Robert S. Huckman & Bradley R. Staats, 2008. "Variation in Experience and Team Familiarity: Addressing the Knowledge Acquisition-Application Problem," Harvard Business School Working Papers 09-035, Harvard Business School.
    8. Robert S. Huckman & Bradley R. Staats, 2011. "Fluid Tasks and Fluid Teams: The Impact of Diversity in Experience and Team Familiarity on Team Performance," Manufacturing & Service Operations Management, INFORMS, vol. 13(3), pages 310-328, July.
    9. Haberstroh, Martin & Wolf, Joachim, 2005. "Individuelle Autonomie in Projektteams," Manuskripte aus den Instituten für Betriebswirtschaftslehre der Universität Kiel 585, Christian-Albrechts-Universität zu Kiel, Institut für Betriebswirtschaftslehre.
    10. Salman Nazir & Brad Price & Nanda C. Surendra & Katherine Kopp, 2022. "Adapting agile development practices for hyper-agile environments: lessons learned from a COVID-19 emergency response research project," Information Technology and Management, Springer, vol. 23(3), pages 193-211, September.
    11. Ciaran Heavey & Zeki Simsek, 2015. "Transactive Memory Systems and Firm Performance: An Upper Echelons Perspective," Organization Science, INFORMS, vol. 26(4), pages 941-959, August.
    12. Shalini R. Tiwari & Rajen Gupta, 2012. "Dynamics of Knowledge Integration in a Project Network," International Journal of Business and Economics, School of Management Development, Feng Chia University, Taichung, Taiwan, vol. 11(2), pages 143-169, December.
    13. Giuri, Paola & Ploner, Matteo & Rullani, Francesco & Torrisi, Salvatore, 2010. "Skills, division of labor and performance in collective inventions: Evidence from open source software," International Journal of Industrial Organization, Elsevier, vol. 28(1), pages 54-68, January.
    14. Shubham Gupta & Abhishek Roy & Subodha Kumar & Ram Mudambi, 2023. "When Worse Is Better: Strategic Choice of Vendors with Differentiated Capabilities in a Complex Cocreation Environment," Management Science, INFORMS, vol. 69(5), pages 2833-2851, May.
    15. Dusya Vera & Mary Crossan, 2005. "Improvisation and Innovative Performance in Teams," Organization Science, INFORMS, vol. 16(3), pages 203-224, June.
    16. Bresciani, Stefano & Ferraris, Alberto & Del Giudice, Manlio, 2018. "The management of organizational ambidexterity through alliances in a new context of analysis: Internet of Things (IoT) smart city projects," Technological Forecasting and Social Change, Elsevier, vol. 136(C), pages 331-338.
    17. Samer Faraj & Yan Xiao, 2006. "Coordination in Fast-Response Organizations," Management Science, INFORMS, vol. 52(8), pages 1155-1169, August.
    18. Mert Günerergin & Cansu Yıldırım, 2013. "Effects of Moral Value Diversity on Team Composition and Team Cohesiveness," Academic Journal of Interdisciplinary Studies, Richtmann Publishing Ltd, vol. 2, October.
    19. Ambos, Tina C. & Ambos, Björn & Eich, Katharina J. & Puck, Jonas, 2016. "Imbalance and Isolation: How Team Configurations Affect Global Knowledge Sharing," Journal of International Management, Elsevier, vol. 22(4), pages 316-332.
    20. Sung‐Choon Kang & Scott A. Snell, 2009. "Intellectual Capital Architectures and Ambidextrous Learning: A Framework for Human Resource Management," Journal of Management Studies, Wiley Blackwell, vol. 46(1), pages 65-92, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:socmed:v:324:y:2023:i:c:s0277953623001466. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/315/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.