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Deep integration: Letting the epigenome out of the bottle without losing sight of the structural origins of population health

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  • Geronimus, A.T.

Abstract

Advances in stress physiology and molecular dynamics can illuminate population health inequality. The "weathering" hypothesis posits that socially structured, repeated stress process activation can accumulate and increase disease vulnerability across the life course in marginalized groups. The developmental origins of health and disease (DOHaD) hypothesis focuses on youthful programming for later life disease via epigenetic modifications to limiting uterine or early environments. Weathering and DOHaD are overlapping biopsychosocial models; yet, their emphases and implications vary. Evidence for the primacy of early development over experiences in young through middle adulthood for explaining population health inequality is lacking. By considering weathering and DOHaD together, we call for biomedical researchers to be more cautious in their claims about the social world and for a broader range of social researchers - including qualitative ones - to collaborate with them.

Suggested Citation

  • Geronimus, A.T., 2013. "Deep integration: Letting the epigenome out of the bottle without losing sight of the structural origins of population health," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 56-63.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2013.301380_6
    DOI: 10.2105/AJPH.2013.301380
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    Cited by:

    1. Man-Kit Lei & Ronald L. Simons, 2021. "The Association between Neighborhood Disorder and Health: Exploring the Moderating Role of Genotype and Marriage," IJERPH, MDPI, vol. 18(3), pages 1-23, January.
    2. Lei, Man-Kit & Berg, Mark T. & Simons, Ronald L. & Beach, Steven R.H., 2022. "Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults," Social Science & Medicine, Elsevier, vol. 293(C).
    3. Walsemann, Katrina M. & Goosby, Bridget J. & Farr, Deeonna, 2016. "Life course SES and cardiovascular risk: Heterogeneity across race/ethnicity and gender," Social Science & Medicine, Elsevier, vol. 152(C), pages 147-155.
    4. Simons, Ronald L. & Lei, Man Kit & Beach, Steven R.H. & Philibert, Robert A. & Cutrona, Carolyn E. & Gibbons, Frederick X. & Barr, Ashley, 2016. "Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women," Social Science & Medicine, Elsevier, vol. 150(C), pages 192-200.
    5. Jeffrey T. Howard & P. Johnelle Sparks, 2016. "The Effects of Allostatic Load on Racial/Ethnic Mortality Differences in the United States," Population Research and Policy Review, Springer;Southern Demographic Association (SDA), vol. 35(4), pages 421-443, August.
    6. Urizar, Guido G. & Nguyen, Vivienne & Devera, Jason & Saquillo, Alexa J. & Dunne, Lauren A. & Brayboy, Cynthia & Dixon-Hamlett, Angela & Clanton-Higgins, Veronica & Manning, Gwendolyn, 2021. "Destined for Greatness: A Family-Based Stress Management Intervention for African-American Mothers and their Children," Social Science & Medicine, Elsevier, vol. 280(C).
    7. Evans, Linnea & Engelman, Michal & Mikulas, Alex & Malecki, Kristen, 2021. "How are social determinants of health integrated into epigenetic research? A systematic review," Social Science & Medicine, Elsevier, vol. 273(C).
    8. Brown, Timothy T. & Partanen, Juulia & Chuong, Linh & Villaverde, Vaughn & Chantal Griffin, Ann & Mendelson, Aaron, 2018. "Discrimination hurts: The effect of discrimination on the development of chronic pain," Social Science & Medicine, Elsevier, vol. 204(C), pages 1-8.

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