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The ratio of morning cortisol to CRP prospectively predicts first-onset depression in at-risk adolescents

Author

Listed:
  • Landau, E.R.
  • Raniti, M.B.
  • Blake, M.
  • Waloszek, J.M.
  • Blake, L.
  • Simmons, J.G.
  • Schwartz, O.
  • Murray, G.
  • Trinder, J.
  • Allen, N.B.
  • Byrne, M.L.

Abstract

Early-onset adolescent depression is related to poor prognosis and a range of psychiatric and medical comorbidities later in life, making the identification of a priori risk factors for depression highly important. Increasingly, dysregulated levels of immune and neuroendocrine markers, such as C-reactive protein (CRP) and cortisol, have been demonstrated as both precursors to and consequences of depression. However, longitudinal research with adolescent populations is limited and demonstrates mixed immuno-endocrine-depression links.

Suggested Citation

  • Landau, E.R. & Raniti, M.B. & Blake, M. & Waloszek, J.M. & Blake, L. & Simmons, J.G. & Schwartz, O. & Murray, G. & Trinder, J. & Allen, N.B. & Byrne, M.L., 2021. "The ratio of morning cortisol to CRP prospectively predicts first-onset depression in at-risk adolescents," Social Science & Medicine, Elsevier, vol. 281(C).
    • Handle: RePEc:eee:socmed:v:281:y:2021:i:c:s0277953621004305
    DOI: 10.1016/j.socscimed.2021.114098
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