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Dynamic model of the force driving kinesin to move along microtubule—Simulation with a model system

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  • Chou, Y.C.
  • Hsiao, Yi-Feng
  • To, Kiwing

Abstract

A dynamic model for the motility of kinesin, including stochastic-force generation and step formation is proposed. The force driving the motion of kinesin motor is generated by the impulse from the collision between the randomly moving long-chain stalk and the ratchet-shaped outer surface of microtubule. Most of the dynamical and statistical features of the motility of kinesin are reproduced in a simulation system, with (a) ratchet structures similar to the outer surface of microtubule, (b) a bead chain connected to two heads, similarly to the stalk of the real kinesin motor, and (c) the interaction between the heads of the simulated kinesin and microtubule. We also propose an experiment to discriminate between the conventional hand-over-hand model and the dynamic model.

Suggested Citation

  • Chou, Y.C. & Hsiao, Yi-Feng & To, Kiwing, 2015. "Dynamic model of the force driving kinesin to move along microtubule—Simulation with a model system," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 433(C), pages 66-73.
    • Handle: RePEc:eee:phsmap:v:433:y:2015:i:c:p:66-73
    DOI: 10.1016/j.physa.2015.03.075
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    References listed on IDEAS

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    1. N. J. Carter & R. A. Cross, 2005. "Mechanics of the kinesin step," Nature, Nature, vol. 435(7040), pages 308-312, May.
    2. Lipowsky, Reinhard & Chai, Yan & Klumpp, Stefan & Liepelt, Steffen & Müller, Melanie J.I., 2006. "Molecular motor traffic: From biological nanomachines to macroscopic transport," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 372(1), pages 34-51.
    3. Koen Visscher & Mark J. Schnitzer & Steven M. Block, 1999. "Single kinesin molecules studied with a molecular force clamp," Nature, Nature, vol. 400(6740), pages 184-189, July.
    4. Wei Hua & Edgar C. Young & Margaret L. Fleming & Jeff Gelles, 1997. "Coupling of kinesin steps to ATP hydrolysis," Nature, Nature, vol. 388(6640), pages 390-393, July.
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    Cited by:

    1. Chou, Y.C., 2019. "Dynamical mechanism of stepping of the molecular motor myosin V along actin filament and simulation in an actual system," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 521(C), pages 399-405.

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