IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v15y2012i12p1263-1271.html
   My bibliography  Save this article

Modelling transport of layered double hydroxide nanoparticles in axons and dendrites of cortical neurons

Author

Listed:
  • A. Kuznetsov

Abstract

This paper develops a model of nanoparticle transport in neurons. It is assumed that nanoparticles are transported inside endocytic vesicles by a combined effect of dynein-driven transport and diffusion. It is further assumed that in axons nanoparticles are internalised only at axon terminals, whereas in dendrites nanoparticles can enter through the entire plasma membrane. This causes differences in transport of nanoparticles in axons and dendrites; these differences are investigated in this paper. Another difference is microtubule (MT) orientation in axons and dendrites; in axons, all MTs have their plus-ends oriented towards the axon terminal; in a proximal region of a dendrite, MTs have mixed orientation, whereas in a distal dendritic region the MT orientation is similar to that in an axon. It is shown that if molecular-motor-driven transport were powered by dynein alone, such MT orientation in a dendrite would result in a region of nanoparticle accumulation located at the border between the proximal and distal dendritic regions.

Suggested Citation

  • A. Kuznetsov, 2012. "Modelling transport of layered double hydroxide nanoparticles in axons and dendrites of cortical neurons," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(12), pages 1263-1271.
    • Handle: RePEc:taf:gcmbxx:v:15:y:2012:i:12:p:1263-1271
    DOI: 10.1080/10255842.2011.585977
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2011.585977
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2011.585977?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Mark E. Davis & Jonathan E. Zuckerman & Chung Hang J. Choi & David Seligson & Anthony Tolcher & Christopher A. Alabi & Yun Yen & Jeremy D. Heidel & Antoni Ribas, 2010. "Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles," Nature, Nature, vol. 464(7291), pages 1067-1070, April.
    2. N. J. Carter & R. A. Cross, 2005. "Mechanics of the kinesin step," Nature, Nature, vol. 435(7040), pages 308-312, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. James F. Cass & Hermes Bloomfield-Gadêlha, 2023. "The reaction-diffusion basis of animated patterns in eukaryotic flagella," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Zhang, Yunxin, 2009. "A general two-cycle network model of molecular motors," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(17), pages 3465-3474.
    3. I.A. Kuznetsov & A.V. Kuznetsov, 2015. "Modelling organelle transport after traumatic axonal injury," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(6), pages 583-591, April.
    4. Chou, Y.C. & Hsiao, Yi-Feng & To, Kiwing, 2015. "Dynamic model of the force driving kinesin to move along microtubule—Simulation with a model system," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 433(C), pages 66-73.
    5. Peter Keller & Sylvie Rœlly & Angelo Valleriani, 2015. "A Quasi Random Walk to Model a Biological Transport Process," Methodology and Computing in Applied Probability, Springer, vol. 17(1), pages 125-137, March.
    6. Tomoko Nakanishi & Julian Willett & Yossi Farjoun & Richard J. Allen & Beatriz Guillen-Guio & Darin Adra & Sirui Zhou & J. Brent Richards, 2023. "Alternative splicing in lung influences COVID-19 severity and respiratory diseases," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    7. Lipowsky, Reinhard & Chai, Yan & Klumpp, Stefan & Liepelt, Steffen & Müller, Melanie J.I., 2006. "Molecular motor traffic: From biological nanomachines to macroscopic transport," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 372(1), pages 34-51.
    8. Hao Wu & Yiyu Chen & Wenlong Xu & Chen Xin & Tao Wu & Wei Feng & Hao Yu & Chao Chen & Shaojun Jiang & Yachao Zhang & Xiaojie Wang & Minghui Duan & Cong Zhang & Shunli Liu & Dawei Wang & Yanlei Hu & Ji, 2023. "High-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    9. A.V. Kuznetsov, 2014. "Sorting of cargos between axons and dendrites: modelling of differences in cargo transport in these two types of neurites," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(7), pages 792-799, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:15:y:2012:i:12:p:1263-1271. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.