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Dynamics of cell aggregates fusion: Experiments and simulations

Author

Listed:
  • Thomas, Gilberto L.
  • Mironov, Vladimir
  • Nagy-Mehez, Agnes
  • Mombach, José C.M.

Abstract

Fusion of cell tissues is an ubiquitous phenomenon and has important technological applications including tissue biofabrication. In this work we present experimental results of aggregates fusion using adipose derived stem cells (ADSC) and a three dimensional computer simulation of the process using the cellular Potts model with aggregates reaching 10,000 cells. We consider fusion of round aggregates and monitor the dimensionless neck area of contact between the two aggregates to characterize the process, as done for the coalescence of liquid droplets and polymers. Both experiments and simulations show that the evolution of this quantity obeys a power law in time. We also study quantitatively individual cell motion with the simulation and it corresponds to an anomalous diffusion.

Suggested Citation

  • Thomas, Gilberto L. & Mironov, Vladimir & Nagy-Mehez, Agnes & Mombach, José C.M., 2014. "Dynamics of cell aggregates fusion: Experiments and simulations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 395(C), pages 247-254.
    • Handle: RePEc:eee:phsmap:v:395:y:2014:i:c:p:247-254
    DOI: 10.1016/j.physa.2013.10.037
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    References listed on IDEAS

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    1. Mombach, José C.M. & Robert, Damien & Graner, François & Gillet, Germain & Thomas, Gilberto L. & Idiart, Marco & Rieu, Jean-Paul, 2005. "Rounding of aggregates of biological cells: Experiments and simulations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 352(2), pages 525-534.
    2. Ouchi, Noriyuki Bob & Glazier, James A. & Rieu, Jean-Paul & Upadhyaya, Arpita & Sawada, Yasuji, 2003. "Improving the realism of the cellular Potts model in simulations of biological cells," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 329(3), pages 451-458.
    3. Upadhyaya, Arpita & Rieu, Jean-Paul & Glazier, James A. & Sawada, Yasuji, 2001. "Anomalous diffusion and non-Gaussian velocity distribution of Hydra cells in cellular aggregates," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 293(3), pages 549-558.
    4. dos Reis, Adriana N & Mombach, José C.M & Walter, M & de Ávila, Leôni F, 2003. "The interplay between cell adhesion and environment rigidity in the morphology of tumors," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 322(C), pages 546-554.
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