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Rounding of aggregates of biological cells: Experiments and simulations

Author

Listed:
  • Mombach, José C.M.
  • Robert, Damien
  • Graner, François
  • Gillet, Germain
  • Thomas, Gilberto L.
  • Idiart, Marco
  • Rieu, Jean-Paul

Abstract

The influence of surface tension and size on rounding of cell aggregates is studied using chick embryonic cells and numerical simulations based on the cellular Potts model. Our results show exponential relaxation in both cases as verified in previous studies using 2D Hydra cell aggregates. The relaxation time decreases with higher surface tension as expected from hydrodynamics laws. However, it increases faster than linearly with aggregate size. The results provide an additional support to the validity of the cellular Potts model for non-equilibrium situations and indicate that aggregate shape relaxation is not governed by the hydrodynamics of viscous liquids.

Suggested Citation

  • Mombach, José C.M. & Robert, Damien & Graner, François & Gillet, Germain & Thomas, Gilberto L. & Idiart, Marco & Rieu, Jean-Paul, 2005. "Rounding of aggregates of biological cells: Experiments and simulations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 352(2), pages 525-534.
    • Handle: RePEc:eee:phsmap:v:352:y:2005:i:2:p:525-534
    DOI: 10.1016/j.physa.2005.02.008
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    Cited by:

    1. Marc Durand, 2021. "Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime," PLOS Computational Biology, Public Library of Science, vol. 17(8), pages 1-13, August.
    2. Thomas, Gilberto L. & Mironov, Vladimir & Nagy-Mehez, Agnes & Mombach, José C.M., 2014. "Dynamics of cell aggregates fusion: Experiments and simulations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 395(C), pages 247-254.

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