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Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime

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  • Marc Durand

Abstract

Cell sorting, whereby a heterogeneous cell mixture segregates and forms distinct homogeneous tissues, is one of the main collective cell behaviors at work during development. Although differences in interfacial energies are recognized to be a possible driving source for cell sorting, no clear consensus has emerged on the kinetic law of cell sorting driven by differential adhesion. Using a modified Cellular Potts Model algorithm that allows for efficient simulations while preserving the connectivity of cells, we numerically explore cell-sorting dynamics over very large scales in space and time. For a binary mixture of cells surrounded by a medium, increase of domain size follows a power-law with exponent n = 1/4 independently of the mixture ratio, revealing that the kinetics is dominated by the diffusion and coalescence of rounded domains. We compare these results with recent numerical studies on cell sorting, and discuss the importance of algorithmic differences as well as boundary conditions on the observed scaling.Author summary: Cell sorting describes the spontaneous segregation of identical cells in biological tissues. This phenomenon is observed during development or organ regeneration in a variety of biological systems. Minimization of the total surface energy of a tissue, in which adhesion strengh between homotypic and heterotypic cells are different, is one of the mechanisms that explain cell sorting. This mechanism is then similar to the one that drives demixing of two immiscible fluids. Because of the high sensibility of this process to finite-size and finite-time effects, no clear consensus has emerged on the scaling law of cell sorting driven by differential adhesion. Using an efficient numerical code, we were able to investigate this scaling law on very large binary mixtures of cells. We show that on long times, cell sorting obeys a universal power law, which is independent of the mixture ratio.

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  • Marc Durand, 2021. "Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime," PLOS Computational Biology, Public Library of Science, vol. 17(8), pages 1-13, August.
    • Handle: RePEc:plo:pcbi00:1008576
    DOI: 10.1371/journal.pcbi.1008576
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    1. Mombach, José C.M. & Robert, Damien & Graner, François & Gillet, Germain & Thomas, Gilberto L. & Idiart, Marco & Rieu, Jean-Paul, 2005. "Rounding of aggregates of biological cells: Experiments and simulations," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 352(2), pages 525-534.
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    Cited by:

    1. Mrinmoy Mukherjee & Herbert Levine, 2021. "Cluster size distribution of cells disseminating from a primary tumor," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-23, November.

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