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Local and global responses in complex gene regulation networks

Author

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  • Tsuchiya, Masa
  • Selvarajoo, Kumar
  • Piras, Vincent
  • Tomita, Masaru
  • Giuliani, Alessandro

Abstract

An exacerbated sensitivity to apparently minor stimuli and a general resilience of the entire system stay together side-by-side in biological systems. This apparent paradox can be explained by the consideration of biological systems as very strongly interconnected network systems. Some nodes of these networks, thanks to their peculiar location in the network architecture, are responsible for the sensitivity aspects, while the large degree of interconnection is at the basis of the resilience properties of the system.

Suggested Citation

  • Tsuchiya, Masa & Selvarajoo, Kumar & Piras, Vincent & Tomita, Masaru & Giuliani, Alessandro, 2009. "Local and global responses in complex gene regulation networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(8), pages 1738-1746.
    • Handle: RePEc:eee:phsmap:v:388:y:2009:i:8:p:1738-1746
    DOI: 10.1016/j.physa.2008.12.030
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    References listed on IDEAS

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    1. Helen Pearson, 2008. "Cell biology: The cellular hullabaloo," Nature, Nature, vol. 453(7192), pages 150-153, May.
    2. Farkas, I. & Jeong, H. & Vicsek, T. & Barabási, A.-L. & Oltvai, Z.N., 2003. "The topology of the transcription regulatory network in the yeast, Saccharomyces cerevisiae," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 318(3), pages 601-612.
    3. H. Jeong & B. Tombor & R. Albert & Z. N. Oltvai & A.-L. Barabási, 2000. "The large-scale organization of metabolic networks," Nature, Nature, vol. 407(6804), pages 651-654, October.
    4. Hannah H. Chang & Martin Hemberg & Mauricio Barahona & Donald E. Ingber & Sui Huang, 2008. "Transcriptome-wide noise controls lineage choice in mammalian progenitor cells," Nature, Nature, vol. 453(7194), pages 544-547, May.
    5. Réka Albert & Hawoong Jeong & Albert-László Barabási, 2000. "Error and attack tolerance of complex networks," Nature, Nature, vol. 406(6794), pages 378-382, July.
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    Cited by:

    1. Wang, Huan & Xu, Chuan-Yun & Hu, Jing-Bo & Cao, Ke-Fei, 2014. "A complex network analysis of hypertension-related genes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 394(C), pages 166-176.
    2. Xue-Yan Zhang & Tian-Yuan He & Chuan-Yun Xu & Ke-Fei Cao & Xu-Sheng Zhang, 2023. "Theoretical investigation of the pathway-based network of type 2 diabetes mellitus-related genes," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 96(6), pages 1-13, June.
    3. Wang, Huan & Hu, Jing-Bo & Xu, Chuan-Yun & Zhang, De-Hai & Yan, Qian & Xu, Ming & Cao, Ke-Fei & Zhang, Xu-Sheng, 2016. "A pathway-based network analysis of hypertension-related genes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 444(C), pages 928-939.

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