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A viral infection model with periodic immune response and nonlinear CTL response

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  • Ji, Yu
  • Min, Lequan
  • Zheng, Yu
  • Su, Yongmei

Abstract

This paper investigates a viral infection model with periodic immune response and nonlinear cytotoxic T lymphocyte (CTL) response. Using the periodic rhythms of human immune system, the model can avoid the unreasonable equilibrium in the basic viral model with nonlinear CTL response introduced by Nowak et al. We obtain the global stability of the infection-free equilibrium and the immune-exhausted equilibrium. Numerical simulations show that the oscillation of immune system can affect the pattern of the viral dynamical behaviors. Period doubling bifurcations of the system are observed via simulations. This can provide a possible interpretation for the viral oscillation behaviors, which were observed in chronic HBV and HCV infection patients.

Suggested Citation

  • Ji, Yu & Min, Lequan & Zheng, Yu & Su, Yongmei, 2010. "A viral infection model with periodic immune response and nonlinear CTL response," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 80(12), pages 2309-2316.
    • Handle: RePEc:eee:matcom:v:80:y:2010:i:12:p:2309-2316
    DOI: 10.1016/j.matcom.2010.04.029
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    References listed on IDEAS

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    1. Wang, Kaifa & Wang, Wendi & Liu, Xianning, 2006. "Viral infection model with periodic lytic immune response," Chaos, Solitons & Fractals, Elsevier, vol. 28(1), pages 90-99.
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    Cited by:

    1. Wang, Tianlei & Hu, Zhixing & Liao, Fucheng & Ma, Wanbiao, 2013. "Global stability analysis for delayed virus infection model with general incidence rate and humoral immunity," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 89(C), pages 13-22.
    2. Xie, Falan & Shan, Meijing & Lian, Xinze & Wang, Weiming, 2017. "Periodic solution of a stochastic HBV infection model with logistic hepatocyte growth," Applied Mathematics and Computation, Elsevier, vol. 293(C), pages 630-641.
    3. Bai, Zhenguo & Zhou, Yicang, 2012. "Dynamics of a viral infection model with delayed CTL response and immune circadian rhythm," Chaos, Solitons & Fractals, Elsevier, vol. 45(9), pages 1133-1139.

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