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A thermodynamic assessment of therapeutic hypothermia techniques

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  • Mady, Carlos Eduardo Keutenedjian
  • Henriques, Izabela Batista
  • de Oliveira, Silvio

Abstract

According to literature, therapeutic hypothermia has been applied for treating conditions that causes an interruption in the delivery of oxygen to the brain, giving the patient better chances of survival with a neurological recovery and without any irreversible damage to the brain. Hypothermia is also used during surgeries and circulatory arrest. In this article, the objective temperature of hypothermia is 32 °C, which is considered mild: 32–35 °C. Three techniques of hypothermia induction were considered: external blood cooling, endovascular cooling with a catheter insertion and water bath. Energy and exergy analyses were performed to determine the clinical effectiveness of these techniques and to evaluate the best test parameters, from which it was possible to calculate the body internal temperature, destroyed exergy and exergy efficiency. Moreover, it was proposed an exergy performance index, which takes into account the ability of a given technique to change the exergy of the body. Results indicate that therapeutic hypothermia takes the subject to a state of lower destroyed exergy and higher body exergy efficiency. The exergy performance index shows that lower rates of cooling lead to a better transformation of the exergy removed from the body into variation of the body exergy.

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  • Mady, Carlos Eduardo Keutenedjian & Henriques, Izabela Batista & de Oliveira, Silvio, 2015. "A thermodynamic assessment of therapeutic hypothermia techniques," Energy, Elsevier, vol. 85(C), pages 392-402.
    • Handle: RePEc:eee:energy:v:85:y:2015:i:c:p:392-402
    DOI: 10.1016/j.energy.2015.03.096
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    References listed on IDEAS

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    1. Genc, S. & Sorguven, E. & Ozilgen, M. & Aksan Kurnaz, I., 2013. "Unsteady exergy destruction of the neuron under dynamic stress conditions," Energy, Elsevier, vol. 59(C), pages 422-431.
    2. Keutenedjian Mady, Carlos Eduardo & Silva Ferreira, Maurício & Itizo Yanagihara, Jurandir & Hilário Nascimento Saldiva, Paulo & de Oliveira Junior, Silvio, 2012. "Modeling the exergy behavior of human body," Energy, Elsevier, vol. 45(1), pages 546-553.
    3. Prek, Matjaz, 2006. "Thermodynamical analysis of human thermal comfort," Energy, Elsevier, vol. 31(5), pages 732-743.
    4. Mady, Carlos Eduardo Keutenedjian & Albuquerque, Cyro & Fernandes, Tiago Lazzaretti & Hernandez, Arnaldo José & Saldiva, Paulo Hilário Nascimento & Yanagihara, Jurandir Itizo & de Oliveira, Silvio, 2013. "Exergy performance of human body under physical activities," Energy, Elsevier, vol. 62(C), pages 370-378.
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    Cited by:

    1. Juliana Rangel Cenzi & Cyro Albuquerque & Carlos Eduardo Keutenedjian Mady, 2019. "Phenomenological and Thermodynamic Model of Gas Exchanges in the Placenta during Pregnancy: A Case Study of Intoxication of Carbon Monoxide," IJERPH, MDPI, vol. 16(21), pages 1-16, October.
    2. Guo, Hongshan & Luo, Yongqiang & Meggers, Forrest & Simonetti, Marco, 2019. "Human body exergy consumption models’ evaluation and their sensitivities towards different environmental conditions," Energy, Elsevier, vol. 183(C), pages 1075-1088.

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