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Fitting marginal accelerated failure time models to clustered survival data with potentially informative cluster size

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  • Fan, Jie
  • Datta, Somnath

Abstract

Methods for analyzing clustered survival data are gaining popularity in biomedical research. Naive attempts to fitting marginal models to such data may lead to biased estimators and misleading inference when the size of a cluster is statistically correlated with some cluster specific latent factors or one or more cluster level covariates. A simple adjustment to correct for potentially informative cluster size is achieved through inverse cluster size reweighting. We give a methodology that incorporates this technique in fitting an accelerated failure time marginal model to clustered survival data. Furthermore, right censoring is handled by inverse probability of censoring reweighting through the use of a flexible model for the censoring hazard. The resulting methodology is examined through a thorough simulation study. Also an illustrative example using a real dataset is provided that examines the effects of age at enrollment and smoking on tooth survival.

Suggested Citation

  • Fan, Jie & Datta, Somnath, 2011. "Fitting marginal accelerated failure time models to clustered survival data with potentially informative cluster size," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3295-3303, December.
  • Handle: RePEc:eee:csdana:v:55:y:2011:i:12:p:3295-3303
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    References listed on IDEAS

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    1. Xiuyu J. Cong & Guosheng Yin & Yu Shen, 2007. "Marginal Analysis of Correlated Failure Time Data with Informative Cluster Sizes," Biometrics, The International Biometric Society, vol. 63(3), pages 663-672, September.
    2. Susmita Datta & Jennifer Le-Rademacher & Somnath Datta, 2007. "Predicting Patient Survival from Microarray Data by Accelerated Failure Time Modeling Using Partial Least Squares and LASSO," Biometrics, The International Biometric Society, vol. 63(1), pages 259-271, March.
    3. Satten, Glen A. & Datta, Somnath & Robins, James, 2001. "Estimating the marginal survival function in the presence of time dependent covariates," Statistics & Probability Letters, Elsevier, vol. 54(4), pages 397-403, October.
    4. John M. Williamson & Somnath Datta & Glen A. Satten, 2003. "Marginal Analyses of Clustered Data When Cluster Size Is Informative," Biometrics, The International Biometric Society, vol. 59(1), pages 36-42, March.
    5. Zhang, Xinyan & Sun, Jianguo, 2010. "Regression analysis of clustered interval-censored failure time data with informative cluster size," Computational Statistics & Data Analysis, Elsevier, vol. 54(7), pages 1817-1823, July.
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    Cited by:

    1. Jie Fan & Somnath Datta, 2013. "On Mann–Whitney tests for comparing sojourn time distributions when the transition times are right censored," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 65(1), pages 149-166, February.
    2. Ling Lan & Dipankar Bandyopadhyay & Somnath Datta, 2017. "Non-parametric regression in clustered multistate current status data with informative cluster size," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 71(1), pages 31-57, January.

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