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Maximum penalized likelihood estimation of additive hazards models with partly interval censoring

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  • Li, Jinqing
  • Ma, Jun

Abstract

Existing likelihood methods for the additive hazards model with interval censored survival data are limited and often ignore the non-negative constraints on hazards. This paper proposes a maximum penalized likelihood method to fit additive hazards models with interval censoring. Our method firstly models the baseline hazard using a finite number of non-negative basis functions, and then regression coefficients and baseline hazard are estimated simultaneously by maximizing a penalized log-likelihood function, where a penalty function is introduced to regularize the baseline hazard estimate. In the estimation procedure, non-negative constraints are imposed on both the baseline hazard and the hazard of each subject. A primal–dual interior-point algorithm is applied to solve the constrained optimization problem. Asymptotic properties are obtained and a simulation study is conducted for assessment of the proposed method.

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  • Li, Jinqing & Ma, Jun, 2019. "Maximum penalized likelihood estimation of additive hazards models with partly interval censoring," Computational Statistics & Data Analysis, Elsevier, vol. 137(C), pages 170-180.
    • Handle: RePEc:eee:csdana:v:137:y:2019:i:c:p:170-180
    DOI: 10.1016/j.csda.2019.02.010
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    References listed on IDEAS

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    1. Marra, Giampiero & Farcomeni, Alessio & Radice, Rosalba, 2021. "Link-based survival additive models under mixed censoring to assess risks of hospital-acquired infections," Computational Statistics & Data Analysis, Elsevier, vol. 155(C).

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