IDEAS home Printed from https://ideas.repec.org/a/eee/csdana/v129y2019icp14-29.html
   My bibliography  Save this article

Bayesian functional joint models for multivariate longitudinal and time-to-event data

Author

Listed:
  • Li, Kan
  • Luo, Sheng

Abstract

A multivariate functional joint model framework is proposed which enables the repeatedly measured functional outcomes, scalar outcomes, and survival process to be modeled simultaneously while accounting for association among the multiple (functional and scalar) longitudinal and survival processes. This data structure is increasingly common across medical studies of neurodegenerative diseases and is exemplified by the motivating Alzheimer’s Disease Neuroimaging Initiative (ADNI) study, in which serial brain imaging, clinical and neuropsychological assessments are collected to measure the progression of Alzheimer’s disease (AD). The proposed functional joint model consists of a longitudinal function-on-scalar submodel, a regular longitudinal submodel, and a survival submodel which allows time-dependent functional and scalar covariates. A Bayesian approach is adopted for parameter estimation and a dynamic prediction framework is introduced for predicting the subjects’ future health outcomes and risk of AD conversion. The proposed model is evaluated by a simulation study and is applied to the motivating ADNI study.

Suggested Citation

  • Li, Kan & Luo, Sheng, 2019. "Bayesian functional joint models for multivariate longitudinal and time-to-event data," Computational Statistics & Data Analysis, Elsevier, vol. 129(C), pages 14-29.
    • Handle: RePEc:eee:csdana:v:129:y:2019:i:c:p:14-29
    DOI: 10.1016/j.csda.2018.07.015
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0167947318301816
    Download Restriction: Full text for ScienceDirect subscribers only.
    File URL: https://libkey.io/10.1016/j.csda.2018.07.015?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Dimitris Rizopoulos, 2011. "Dynamic Predictions and Prospective Accuracy in Joint Models for Longitudinal and Time-to-Event Data," Biometrics, The International Biometric Society, vol. 67(3), pages 819-829, September.
    2. Crainiceanu, Ciprian M. & Staicu, Ana-Maria & Di, Chong-Zhi, 2009. "Generalized Multilevel Functional Regression," Journal of the American Statistical Association, American Statistical Association, vol. 104(488), pages 1550-1561.
    3. Dunson, David B., 2003. "Dynamic Latent Trait Models for Multidimensional Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 98, pages 555-563, January.
    4. Crainiceanu, Ciprian M. & Goldsmith, A. Jeffrey, 2010. "Bayesian Functional Data Analysis Using WinBUGS," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 32(i11).
    5. Wensheng Guo, 2002. "Functional Mixed Effects Models," Biometrics, The International Biometric Society, vol. 58(1), pages 121-128, March.
    6. Jeffrey S. Morris & Raymond J. Carroll, 2006. "Wavelet‐based functional mixed models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(2), pages 179-199, April.
    7. W. R. Gilks & N. G. Best & K. K. C. Tan, 1995. "Adaptive Rejection Metropolis Sampling Within Gibbs Sampling," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 44(4), pages 455-472, December.
    8. Ruppert,David & Wand,M. P. & Carroll,R. J., 2003. "Semiparametric Regression," Cambridge Books, Cambridge University Press, number 9780521785167, September.
    9. Jeff Goldsmith & Tomoko Kitago, 2016. "Assessing systematic effects of stroke on motor control by using hierarchical function-on-scalar regression," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 65(2), pages 215-236, February.
    10. Dimitris Rizopoulos & Laura A. Hatfield & Bradley P. Carlin & Johanna J. M. Takkenberg, 2014. "Combining Dynamic Predictions From Joint Models for Longitudinal and Time-to-Event Data Using Bayesian Model Averaging," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(508), pages 1385-1397, December.
    11. Jeff Goldsmith & Vadim Zipunnikov & Jennifer Schrack, 2015. "Generalized multilevel function-on-scalar regression and principal component analysis," Biometrics, The International Biometric Society, vol. 71(2), pages 344-353, June.
    12. Ruppert,David & Wand,M. P. & Carroll,R. J., 2003. "Semiparametric Regression," Cambridge Books, Cambridge University Press, number 9780521780506, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Khurshid Alam & Arnab Maity & Sanjoy K. Sinha & Dimitris Rizopoulos & Abdus Sattar, 2021. "Joint modeling of longitudinal continuous, longitudinal ordinal, and time-to-event outcomes," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(1), pages 64-90, January.
    2. Zhang, Zili & Charalambous, Christiana & Foster, Peter, 2023. "A Gaussian copula joint model for longitudinal and time-to-event data with random effects," Computational Statistics & Data Analysis, Elsevier, vol. 181(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Li, Yehua & Qiu, Yumou & Xu, Yuhang, 2022. "From multivariate to functional data analysis: Fundamentals, recent developments, and emerging areas," Journal of Multivariate Analysis, Elsevier, vol. 188(C).
    2. Jeff Goldsmith & Vadim Zipunnikov & Jennifer Schrack, 2015. "Generalized multilevel function-on-scalar regression and principal component analysis," Biometrics, The International Biometric Society, vol. 71(2), pages 344-353, June.
    3. Lin Zhang & Veerabhadran Baladandayuthapani & Hongxiao Zhu & Keith A. Baggerly & Tadeusz Majewski & Bogdan A. Czerniak & Jeffrey S. Morris, 2016. "Functional CAR Models for Large Spatially Correlated Functional Datasets," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(514), pages 772-786, April.
    4. Yukun Zhang & Haocheng Li & Sarah Kozey Keadle & Charles E. Matthews & Raymond J. Carroll, 2019. "A Review of Statistical Analyses on Physical Activity Data Collected from Accelerometers," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 11(2), pages 465-476, July.
    5. Rosen, Ori & Thompson, Wesley K., 2009. "A Bayesian regression model for multivariate functional data," Computational Statistics & Data Analysis, Elsevier, vol. 53(11), pages 3773-3786, September.
    6. Andrada Ivanescu & Ana-Maria Staicu & Fabian Scheipl & Sonja Greven, 2015. "Penalized function-on-function regression," Computational Statistics, Springer, vol. 30(2), pages 539-568, June.
    7. Li, Yehua & Hsing, Tailen, 2007. "On rates of convergence in functional linear regression," Journal of Multivariate Analysis, Elsevier, vol. 98(9), pages 1782-1804, October.
    8. Gertheiss, Jan & Goldsmith, Jeff & Staicu, Ana-Maria, 2017. "A note on modeling sparse exponential-family functional response curves," Computational Statistics & Data Analysis, Elsevier, vol. 105(C), pages 46-52.
    9. Kruse, René-Marcel & Silbersdorff, Alexander & Säfken, Benjamin, 2022. "Model averaging for linear mixed models via augmented Lagrangian," Computational Statistics & Data Analysis, Elsevier, vol. 167(C).
    10. Ghosal, Rahul & Maity, Arnab, 2022. "A Score Based Test for Functional Linear Concurrent Regression," Econometrics and Statistics, Elsevier, vol. 21(C), pages 114-130.
    11. Yu Yue & Paul Speckman & Dongchu Sun, 2012. "Priors for Bayesian adaptive spline smoothing," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 64(3), pages 577-613, June.
    12. Mark J. Meyer & Haobo Cheng & Katherine Hobbs Knutson, 2023. "Bayesian Analysis of Multivariate Matched Proportions with Sparse Response," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 15(2), pages 490-509, July.
    13. Huaihou Chen & Yuanjia Wang, 2011. "A Penalized Spline Approach to Functional Mixed Effects Model Analysis," Biometrics, The International Biometric Society, vol. 67(3), pages 861-870, September.
    14. Philip T. Reiss & Jeff Goldsmith & Han Lin Shang & R. Todd Ogden, 2017. "Methods for Scalar-on-Function Regression," International Statistical Review, International Statistical Institute, vol. 85(2), pages 228-249, August.
    15. Ana-Maria Staicu & Ciprian M. Crainiceanu & Daniel S. Reich & David Ruppert, 2012. "Modeling Functional Data with Spatially Heterogeneous Shape Characteristics," Biometrics, The International Biometric Society, vol. 68(2), pages 331-343, June.
    16. Cai, Bo & Meyer, Renate, 2011. "Bayesian semiparametric modeling of survival data based on mixtures of B-spline distributions," Computational Statistics & Data Analysis, Elsevier, vol. 55(3), pages 1260-1272, March.
    17. Wang, Shikun & Li, Zhao & Lan, Lan & Zhao, Jieyi & Zheng, W. Jim & Li, Liang, 2022. "GPU accelerated estimation of a shared random effect joint model for dynamic prediction," Computational Statistics & Data Analysis, Elsevier, vol. 174(C).
    18. Mark J. Meyer & Brent A. Coull & Francesco Versace & Paul Cinciripini & Jeffrey S. Morris, 2015. "Bayesian function‐on‐function regression for multilevel functional data," Biometrics, The International Biometric Society, vol. 71(3), pages 563-574, September.
    19. Mengfei Ran & Yihe Yang, 2022. "Optimal Estimation of Large Functional and Longitudinal Data by Using Functional Linear Mixed Model," Mathematics, MDPI, vol. 10(22), pages 1-28, November.
    20. Jonathan E. Gellar & Elizabeth Colantuoni & Dale M. Needham & Ciprian M. Crainiceanu, 2014. "Variable-Domain Functional Regression for Modeling ICU Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(508), pages 1425-1439, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:129:y:2019:i:c:p:14-29. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/csda .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.