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A multiple imputation approach to the analysis of clustered interval-censored failure time data with the additive hazards model

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  • Chen, Ling
  • Sun, Jianguo
  • Xiong, Chengjie

Abstract

Clustered interval-censored failure time data can occur when the failure time of interest is collected from several clusters and known only within certain time intervals. Regression analysis of clustered interval-censored failure time data is discussed assuming that the data arise from the semiparametric additive hazards model. A multiple imputation approach is proposed for inference. A major advantage of the approach is its simplicity because it avoids estimating the correlation within clusters by implementing a resampling-based method. The presented approach can be easily implemented by using the existing software packages for right-censored failure time data. Extensive simulation studies are conducted, indicating that the proposed imputation approach performs well for practical situations. The proposed approach also performs well compared to the existing methods and can be more conveniently applied to various types of data representation. The proposed methodology is further demonstrated by applying it to a lymphatic filariasis study.

Suggested Citation

  • Chen, Ling & Sun, Jianguo & Xiong, Chengjie, 2016. "A multiple imputation approach to the analysis of clustered interval-censored failure time data with the additive hazards model," Computational Statistics & Data Analysis, Elsevier, vol. 103(C), pages 242-249.
    • Handle: RePEc:eee:csdana:v:103:y:2016:i:c:p:242-249
    DOI: 10.1016/j.csda.2016.05.011
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    References listed on IDEAS

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    1. Zhang, Xinyan & Sun, Jianguo, 2010. "Regression analysis of clustered interval-censored failure time data with informative cluster size," Computational Statistics & Data Analysis, Elsevier, vol. 54(7), pages 1817-1823, July.
    2. Wei Pan, 2000. "A Multiple Imputation Approach to Cox Regression with Interval-Censored Data," Biometrics, The International Biometric Society, vol. 56(1), pages 199-203, March.
    3. Junlong Li & Chunjie Wang & Jianguo Sun, 2012. "Regression analysis of clustered interval-censored failure time data with the additive hazards model," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 24(4), pages 1041-1050, December.
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