IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v170y2023ics0960077923002321.html
   My bibliography  Save this article

Fractional order bacterial infection model with effects of anti-virulence drug and antibiotic

Author

Listed:
  • Daşbaşı, Bahatdin

Abstract

A model examining the population dynamics of susceptible bacteria, resistant bacteria, adaptive immunity cells and innate cells in an infected individual receiving multiple antibiotics and antivirulence drug is proposed by a fractional-order differential equations in Caputo sense. The existence and uniqueness of the solutions the model as well as their non-negativity and boundedness have been discussed. The reproduction numbers of the proposed model through the next generation matrix procedure are developed. The existence and stability of the equilibrium points were shown. To demonstrate the model's ability to be applicable on a real-world example, the numerical simulations were carried out by using parameter values acquired from the literature for Mycobacterium Tuberculosis (Mtb) and Pseudomonas Aeruginosa (Pa). The effects of antivirulence drug therapy in addition to antibiotic therapy have been also investigated. The role of antivirulence drug therapy in eliminating infectious bacteria was discussed in the simulations obtained in accordance with the recommended treatment processes for these bacteria. In addition, the model was simplified by considering the situation in which no drug treatment was administered, and its analysis was also carried out. Sensitivity analysis of the reproduction numbers was performed in the light of the values used in simulations.

Suggested Citation

  • Daşbaşı, Bahatdin, 2023. "Fractional order bacterial infection model with effects of anti-virulence drug and antibiotic," Chaos, Solitons & Fractals, Elsevier, vol. 170(C).
    • Handle: RePEc:eee:chsofr:v:170:y:2023:i:c:s0960077923002321
    DOI: 10.1016/j.chaos.2023.113331
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077923002321
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2023.113331?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Qu, Haidong & Rahman, Mati ur & Ahmad, Shabir & Riaz, Muhammad Bilal & Ibrahim, Muhammaad & Saeed, Tareq, 2022. "Investigation of fractional order bacteria dependent disease with the effects of different contact rates," Chaos, Solitons & Fractals, Elsevier, vol. 159(C).
    2. Md Rafiul Islam & Angela Peace & Daniel Medina & Tamer Oraby, 2020. "Integer Versus Fractional Order SEIR Deterministic and Stochastic Models of Measles," IJERPH, MDPI, vol. 17(6), pages 1-19, March.
    3. Ji, Guilin & Ge, Qing & Xu, Jiabo, 2016. "Dynamic behaviors of a fractional order two-species cooperative systems with harvesting," Chaos, Solitons & Fractals, Elsevier, vol. 92(C), pages 51-55.
    4. Adnane Boukhouima & Khalid Hattaf & Noura Yousfi, 2017. "Dynamics of a Fractional Order HIV Infection Model with Specific Functional Response and Cure Rate," International Journal of Differential Equations, Hindawi, vol. 2017, pages 1-8, August.
    5. Xu, Changjin & Alhejaili, Weaam & Saifullah, Sayed & Khan, Arshad & Khan, Javed & El-Shorbagy, M.A., 2022. "Analysis of Huanglongbing disease model with a novel fractional piecewise approach," Chaos, Solitons & Fractals, Elsevier, vol. 161(C).
    6. Ullah, Ihsan & Ahmad, Saeed & Rahman, Mati ur & Arfan, Muhammad, 2021. "Investigation of fractional order tuberculosis (TB) model via Caputo derivative," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    7. Baleanu, Dumitru & Jajarmi, Amin & Mohammadi, Hakimeh & Rezapour, Shahram, 2020. "A new study on the mathematical modelling of human liver with Caputo–Fabrizio fractional derivative," Chaos, Solitons & Fractals, Elsevier, vol. 134(C).
    8. Ali Turab & Norhayati Rosli, 2022. "Study of Fractional Differential Equations Emerging in the Theory of Chemical Graphs: A Robust Approach," Mathematics, MDPI, vol. 10(22), pages 1-16, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kumar, Sunil & Chauhan, R.P. & Momani, Shaher & Hadid, Samir, 2021. "A study of fractional TB model due to mycobacterium tuberculosis bacteria," Chaos, Solitons & Fractals, Elsevier, vol. 153(P2).
    2. Danane, Jaouad & Allali, Karam & Hammouch, Zakia, 2020. "Mathematical analysis of a fractional differential model of HBV infection with antibody immune response," Chaos, Solitons & Fractals, Elsevier, vol. 136(C).
    3. Kritika, & Agarwal, Ritu & Purohit, Sunil Dutt, 2020. "Mathematical model for anomalous subdiffusion using comformable operator," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    4. Abdelhamid Mohammed Djaouti & Zareen A. Khan & Muhammad Imran Liaqat & Ashraf Al-Quran, 2024. "A Study of Some Generalized Results of Neutral Stochastic Differential Equations in the Framework of Caputo–Katugampola Fractional Derivatives," Mathematics, MDPI, vol. 12(11), pages 1-20, May.
    5. Ullah, Ihsan & Ahmad, Saeed & Rahman, Mati ur & Arfan, Muhammad, 2021. "Investigation of fractional order tuberculosis (TB) model via Caputo derivative," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    6. Hussain, Ghulam & Khan, Amir & Zahri, Mostafa & Zaman, Gul, 2022. "Ergodic stationary distribution of stochastic epidemic model for HBV with double saturated incidence rates and vaccination," Chaos, Solitons & Fractals, Elsevier, vol. 160(C).
    7. Alam, Mehboob & Zada, Akbar, 2022. "Implementation of q-calculus on q-integro-differential equation involving anti-periodic boundary conditions with three criteria," Chaos, Solitons & Fractals, Elsevier, vol. 154(C).
    8. Liaqat, Muhammad Imran & Akgül, Ali, 2022. "A novel approach for solving linear and nonlinear time-fractional Schrödinger equations," Chaos, Solitons & Fractals, Elsevier, vol. 162(C).
    9. Yahya Almalki & Waqar Afzal, 2023. "Some New Estimates of Hermite–Hadamard Inequalities for Harmonical cr - h -Convex Functions via Generalized Fractional Integral Operator on Set-Valued Mappings," Mathematics, MDPI, vol. 11(19), pages 1-21, September.
    10. Boukhouima, Adnane & Hattaf, Khalid & Lotfi, El Mehdi & Mahrouf, Marouane & Torres, Delfim F.M. & Yousfi, Noura, 2020. "Lyapunov functions for fractional-order systems in biology: Methods and applications," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    11. Hari Mohan Srivastava & Khaled M. Saad, 2020. "A Comparative Study of the Fractional-Order Clock Chemical Model," Mathematics, MDPI, vol. 8(9), pages 1-14, August.
    12. Ghanbari, Behzad, 2021. "On detecting chaos in a prey-predator model with prey’s counter-attack on juvenile predators," Chaos, Solitons & Fractals, Elsevier, vol. 150(C).
    13. Li, Peiluan & Gao, Rong & Xu, Changjin & Ahmad, Shabir & Li, Ying & Akgül, Ali, 2023. "Bifurcation behavior and PDγ control mechanism of a fractional delayed genetic regulatory model," Chaos, Solitons & Fractals, Elsevier, vol. 168(C).
    14. Chaudhary, Naveed Ishtiaq & Raja, Muhammad Asif Zahoor & Khan, Zeshan Aslam & Mehmood, Ammara & Shah, Syed Muslim, 2022. "Design of fractional hierarchical gradient descent algorithm for parameter estimation of nonlinear control autoregressive systems," Chaos, Solitons & Fractals, Elsevier, vol. 157(C).
    15. Alina Alb Lupaş, 2021. "Applications of the Fractional Calculus in Fuzzy Differential Subordinations and Superordinations," Mathematics, MDPI, vol. 9(20), pages 1-10, October.
    16. Ahmad, Shabir & Ullah, Aman & Arfan, Muhammad & Shah, Kamal, 2020. "On analysis of the fractional mathematical model of rotavirus epidemic with the effects of breastfeeding and vaccination under Atangana-Baleanu (AB) derivative," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    17. Attia, Nourhane & Akgül, Ali & Seba, Djamila & Nour, Abdelkader, 2020. "An efficient numerical technique for a biological population model of fractional order," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    18. Singh, Harendra, 2021. "Analysis of drug treatment of the fractional HIV infection model of CD4+ T-cells," Chaos, Solitons & Fractals, Elsevier, vol. 146(C).
    19. DAŞBAŞI, Bahatdin, 2020. "Stability analysis of the hiv model through incommensurate fractional-order nonlinear system," Chaos, Solitons & Fractals, Elsevier, vol. 137(C).
    20. Kumar, Pushpendra & Govindaraj, V. & Erturk, Vedat Suat, 2022. "A novel mathematical model to describe the transmission dynamics of tooth cavity in the human population," Chaos, Solitons & Fractals, Elsevier, vol. 161(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:170:y:2023:i:c:s0960077923002321. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.