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Modelling immune systems based on Atangana–Baleanu fractional derivative

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  • Al-khedhairi, A.
  • Elsadany, A.A.
  • Elsonbaty, A.

Abstract

Memory effects play a critical role in complex immune systems. In this paper, the recent efficient and realistic Atangana–Baleanu fractional order derivative, with non-local and non-singular kernel, was employed in two mathematical models for immune systems having multiple immune effectors. For each model, we derive the conditions under which a unique set of exact solutions exists. Stability analysis of equilibrium points of the two systems is carried out where the effects of model’s parameters and fractional derivatives are examined. Furthermore, a recent numerical scheme is utilized to solve each model numerically and to compare theoretical results with those of numerical experiments. Results depict that memory influences induce stabilization of immune systems such that the solution trajectories of the model always converge to either a single immune effector or a persistent immune effector/antigen equilibrium states.

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  • Al-khedhairi, A. & Elsadany, A.A. & Elsonbaty, A., 2019. "Modelling immune systems based on Atangana–Baleanu fractional derivative," Chaos, Solitons & Fractals, Elsevier, vol. 129(C), pages 25-39.
  • Handle: RePEc:eee:chsofr:v:129:y:2019:i:c:p:25-39
    DOI: 10.1016/j.chaos.2019.07.053
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    References listed on IDEAS

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    Cited by:

    1. Kamal, F.M. & Elsonbaty, A. & Elsaid, A., 2021. "A novel fractional nonautonomous chaotic circuit model and its application to image encryption," Chaos, Solitons & Fractals, Elsevier, vol. 144(C).
    2. Skwara, Urszula & Mozyrska, Dorota & Aguiar, Maira & Stollenwerk, Nico, 2024. "Dynamics of vector-borne diseases through the lens of systems incorporating fractional-order derivatives," Chaos, Solitons & Fractals, Elsevier, vol. 181(C).
    3. Dalal Yahya Alzahrani & Fuaada Mohd Siam & Farah A. Abdullah, 2023. "Elucidating the Effects of Ionizing Radiation on Immune Cell Populations: A Mathematical Modeling Approach with Special Emphasis on Fractional Derivatives," Mathematics, MDPI, vol. 11(7), pages 1-21, April.
    4. Muñoz-Vázquez, Aldo Jonathan & Sánchez-Torres, Juan Diego & Defoort, Michael & Boulaaras, Salah, 2021. "Predefined-time convergence in fractional-order systems," Chaos, Solitons & Fractals, Elsevier, vol. 143(C).

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