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Epistatic Interactions

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  • VanderWeele Tyler J

    (Harvard University)

Abstract

The term "epistasis" is sometimes used to describe some form of statistical interaction between genetic factors and is alternatively sometimes used to describe instances in which the effect of a particular genetic variant is masked by a variant at another locus. In general statistical tests for interaction are of limited use in detecting "epistasis" in the sense of masking. It is, however, shown that there are relations between empirical data patterns and epistasis that have not been previously noted. These relations can sometimes be exploited to empirically test for "epistatic interactions" in the sense of the masking of the effect of a particular genetic variant by a variant at another locus.

Suggested Citation

  • VanderWeele Tyler J, 2010. "Epistatic Interactions," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 9(1), pages 1-24, January.
    • Handle: RePEc:bpj:sagmbi:v:9:y:2010:i:1:n:1
    DOI: 10.2202/1544-6115.1517
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    References listed on IDEAS

    as
    1. Tyler J. Vanderweele & James M. Robins, 2008. "Empirical and counterfactual conditions for sufficient cause interactions," Biometrika, Biometrika Trust, vol. 95(1), pages 49-61.
    2. Vansteelandt, Stijn & VanderWeele, Tyler J. & Tchetgen, Eric J. & Robins, James M., 2008. "Multiply Robust Inference for Statistical Interactions," Journal of the American Statistical Association, American Statistical Association, vol. 103(484), pages 1693-1704.
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    Cited by:

    1. Binder Harald & Müller Tina & Schwender Holger & Golka Klaus & Steffens Michael & Hengstler Jan G. & Ickstadt Katja & Schumacher Martin, 2012. "Cluster-Localized Sparse Logistic Regression for SNP Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(4), pages 1-31, August.
    2. Carlo Berzuini & A. Philip Dawid, 2016. "Stochastic mechanistic interaction," Biometrika, Biometrika Trust, vol. 103(1), pages 89-102.
    3. VanderWeele Tyler J, 2010. "Attributable Fractions for Sufficient Cause Interactions," The International Journal of Biostatistics, De Gruyter, vol. 6(2), pages 1-28, February.
    4. VanderWeele Tyler J, 2011. "Principal Stratification -- Uses and Limitations," The International Journal of Biostatistics, De Gruyter, vol. 7(1), pages 1-14, July.

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