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Dose-Finding Based on Efficacy–Toxicity Trade-Offs

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  • Peter F. Thall
  • John D. Cook

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  • Peter F. Thall & John D. Cook, 2004. "Dose-Finding Based on Efficacy–Toxicity Trade-Offs," Biometrics, The International Biometric Society, vol. 60(3), pages 684-693, September.
    • Handle: RePEc:bla:biomet:v:60:y:2004:i:3:p:684-693
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    File URL: http://hdl.handle.net/10.1111/j.0006-341X.2004.00218.x
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    Citations

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    Cited by:

    1. Alam, M. Iftakhar & Bogacka, Barbara & Coad, D. Stephen, 2017. "Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials," Computational Statistics & Data Analysis, Elsevier, vol. 111(C), pages 183-202.
    2. Shenghua Fan & Bee Leng Lee & Ying Lu, 2020. "A Curve-Free Bayesian Decision-Theoretic Design for Phase Ia/Ib Trials Considering Both Safety and Efficacy Outcomes," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(2), pages 146-166, July.
    3. Nadine Houede & Peter F. Thall & Hoang Nguyen & Xavier Paoletti & Andrew Kramar, 2010. "Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials," Biometrics, The International Biometric Society, vol. 66(2), pages 532-540, June.
    4. Souvik Banerjee & Triparna Bose & Vijay M. Patil & Atanu Bhattacharjee & Kumar Prabhash, 2023. "Bayesian Effective Biological Dose Determination in Immunotherapy Response Trial," Annals of Data Science, Springer, vol. 10(1), pages 209-223, February.
    5. Peter F. Thall & Hoang Q. Nguyen & Ralph G. Zinner, 2017. "Parametric dose standardization for optimizing two-agent combinations in a phase I–II trial with ordinal outcomes," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(1), pages 201-224, January.
    6. Ying Yuan & Guosheng Yin, 2009. "Bayesian dose finding by jointly modelling toxicity and efficacy as time‐to‐event outcomes," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 58(5), pages 719-736, December.
    7. Christophe Le Tourneau & Hui K Gan & Albiruni R A Razak & Xavier Paoletti, 2012. "Efficiency of New Dose Escalation Designs in Dose-Finding Phase I Trials of Molecularly Targeted Agents," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-3, December.
    8. Peter F. Thall & Hoang Q. Nguyen & Thomas M. Braun & Muzaffar H. Qazilbash, 2013. "Using Joint Utilities of the Times to Response and Toxicity to Adaptively Optimize Schedule–Dose Regimes," Biometrics, The International Biometric Society, vol. 69(3), pages 673-682, September.
    9. Peter F. Thall & Aniko Szabo & Hoang Q. Nguyen & Catherine M. Amlie-Lefond & Osama O. Zaidat, 2011. "Optimizing the Concentration and Bolus of a Drug Delivered by Continuous Infusion," Biometrics, The International Biometric Society, vol. 67(4), pages 1638-1646, December.
    10. B. Nebiyou Bekele & Yu Shen, 2005. "A Bayesian Approach to Jointly Modeling Toxicity and Biomarker Expression in a Phase I/II Dose-Finding Trial," Biometrics, The International Biometric Society, vol. 61(2), pages 343-354, June.
    11. Chunyan Cai & Ying Yuan & Yuan Ji, 2014. "A Bayesian dose finding design for oncology clinical trials of combinational biological agents," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 63(1), pages 159-173, January.
    12. Laura Deldossi & Silvia Angela Osmetti & Chiara Tommasi, 2019. "Optimal design to discriminate between rival copula models for a bivariate binary response," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(1), pages 147-165, March.
    13. Ying Kuen Cheung, 2014. "Simple benchmark for complex dose finding studies," Biometrics, The International Biometric Society, vol. 70(2), pages 389-397, June.
    14. Jay Bartroff & Tze Leung Lai, 2011. "Incorporating Individual and Collective Ethics into Phase I Cancer Trial Designs," Biometrics, The International Biometric Society, vol. 67(2), pages 596-603, June.
    15. Peter F. Thall & Hoang Q. Nguyen & Elihu H. Estey, 2008. "Patient-Specific Dose Finding Based on Bivariate Outcomes and Covariates," Biometrics, The International Biometric Society, vol. 64(4), pages 1126-1136, December.
    16. Yuxi Tao & Junlin Liu & Zhihui Li & Jinguan Lin & Tao Lu & Fangrong Yan, 2013. "Dose-Finding Based on Bivariate Efficacy-Toxicity Outcome Using Archimedean Copula," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-6, November.
    17. Sergei Leonov & Bahjat Qaqish, 2020. "Correlated endpoints: simulation, modeling, and extreme correlations," Statistical Papers, Springer, vol. 61(2), pages 741-766, April.
    18. Guosheng Yin & Yisheng Li & Yuan Ji, 2006. "Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios," Biometrics, The International Biometric Society, vol. 62(3), pages 777-787, September.

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