IDEAS home Printed from https://ideas.repec.org/p/pra/mprapa/52899.html
   My bibliography  Save this paper

R&D models: lessons from vaccine history

Author

Listed:
  • Wilson, Paul
  • Post, Sarah
  • Srinivas, Smita

Abstract

A preventive HIV vaccine offers the best hope for ending the AIDS pandemic. Scientific evidence suggests that an HIV vaccine is possible, and funding for HIV vaccine research and development (R&D) has increased substantially in recent years. The speed of progress toward an HIV vaccine will depend on the management of the effort as well as on its scale, however, and organizational issues have been the subject of vigorous debate. With this paper, we seek to shed light on these debates by examining the history of vaccine development, as well as some examples of large R&D initiatives in other areas. We focus on two issues: the roles of the public and private sectors, and the merits and risks of strong central direction of R&D. We also consider the scientific, regulatory, and institutional changes that complicate extrapolation from past experience to the case of HIV vaccines. Our analysis draws on extensive interviews with experts in the field as well as a literature review.

Suggested Citation

  • Wilson, Paul & Post, Sarah & Srinivas, Smita, 2007. "R&D models: lessons from vaccine history," MPRA Paper 52899, University Library of Munich, Germany.
    • Handle: RePEc:pra:mprapa:52899
    as

    Download full text from publisher

    File URL: https://mpra.ub.uni-muenchen.de/52899/1/MPRA_paper_52899.pdf
    File Function: original version
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Blume, Stuart S., 2005. "Lock in, the state and vaccine development: Lessons from the history of the polio vaccines," Research Policy, Elsevier, vol. 34(2), pages 159-173, March.
    2. Baker, J.P., 2000. "Immunization and the American way: 4 Childhood vaccines," American Journal of Public Health, American Public Health Association, vol. 90(2), pages 199-207.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ming-Sin Choong & Ying-Che Hsieh & Chan-Yuan Wong, 2024. "Resilient or Resistant: Pandemic Crisis and Early Observations of Different Preventive Capabilities from Cumulativeness of Scientific Research Points of View," Journal of the Knowledge Economy, Springer;Portland International Center for Management of Engineering and Technology (PICMET), vol. 15(3), pages 11976-12005, September.
    2. Yaqub, Ohid, 2017. "Testing regimes in clinical trials: Evidence from four polio vaccine trajectories," Research Policy, Elsevier, vol. 46(2), pages 475-484.
    3. Bustamante, Juana & Oughton, Christine & Pesque-Cela, Vanesa & Tobin, Damian, 2023. "Resolving the patents paradox in the era of COVID-19 and climate change: Towards a patents taxonomy," Research Policy, Elsevier, vol. 52(9).
    4. Trifunović Vesna, 2024. "Vaccine as a Sociocultural Artefact: The Example of Locally Produced Polio Vaccine in Serbia," Comparative Southeast European Studies, De Gruyter, vol. 72(1), pages 13-32, March.
    5. Blume, Stuart & Tump, Janneke, 2010. "Evidence and policymaking: The introduction of MMR vaccine in the Netherlands," Social Science & Medicine, Elsevier, vol. 71(6), pages 1049-1055, September.
    6. Serratos-Sotelo, L.;, 2019. "Were there long-term economic effects of exposure to Polio Vaccination?: An analysis of migrants to Sweden 1946-2003," Health, Econometrics and Data Group (HEDG) Working Papers 19/19, HEDG, c/o Department of Economics, University of York.
    7. Blume, Stuart & Zanders, Mariska, 2006. "Vaccine independence, local competences and globalisation: Lessons from the history of pertussis vaccines," Social Science & Medicine, Elsevier, vol. 63(7), pages 1825-1835, October.
    8. Yaqub, Ohid & Nightingale, Paul, 2012. "Vaccine innovation, translational research and the management of knowledge accumulation," Social Science & Medicine, Elsevier, vol. 75(12), pages 2143-2150.
    9. Beniamino Callegari & Christophe Feder, 2022. "The long-term economic effects of pandemics: toward an evolutionary approach [Epidemics and trust: the case of the Spanish flu]," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 31(3), pages 715-735.

    More about this item

    Keywords

    R&D; vaccine; AIDS; public; private; institution;
    All these keywords.

    JEL classification:

    • I1 - Health, Education, and Welfare - - Health
    • O3 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights
    • O32 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Management of Technological Innovation and R&D

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:pra:mprapa:52899. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Joachim Winter (email available below). General contact details of provider: https://edirc.repec.org/data/vfmunde.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.