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Vaccine innovation, translational research and the management of knowledge accumulation

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  • Yaqub, Ohid
  • Nightingale, Paul

Abstract

What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving processes that generate knowledge which is often fragmented and only locally valid. This paper details some of the conditions that allow fragmented, local knowledge to accumulate through a series of structured steps from the artificial simplicity of the laboratory to the complexity of real world application. Poliomyelitis is used as an illustrative case to highlight the importance of experimental animal models and the extent of co-ordination that can be required if they are missing. Implications for the governance and management of current attempts to produce vaccines for HIV, TB and Malaria are discussed.

Suggested Citation

  • Yaqub, Ohid & Nightingale, Paul, 2012. "Vaccine innovation, translational research and the management of knowledge accumulation," Social Science & Medicine, Elsevier, vol. 75(12), pages 2143-2150.
    • Handle: RePEc:eee:socmed:v:75:y:2012:i:12:p:2143-2150
    DOI: 10.1016/j.socscimed.2012.07.023
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    3. Wallace, Matthew L. & Ràfols, Ismael, 2018. "Institutional shaping of research priorities: A case study on avian influenza," Research Policy, Elsevier, vol. 47(10), pages 1975-1989.
    4. Blandinieres, Florence, 2019. "Anatomy of the medical innovation process: What are the consequences of replicability issues on innovation?," ZEW Discussion Papers 19-011, ZEW - Leibniz Centre for European Economic Research.
    5. Paul Nightingale, 2014. "What is technology? Six definitions and two pathologies," SPRU Working Paper Series 2014-19, SPRU - Science Policy Research Unit, University of Sussex Business School.
    6. Fonseca, Elize Massard da & Shadlen, Kenneth C. & Achcar, Helena de Moraes, 2023. "Vaccine technology transfer in a global health crisis: Actors, capabilities, and institutions," Research Policy, Elsevier, vol. 52(4).
    7. Yaqub, Ohid & Castle-Clarke, Sophie & Sevdalis, Nick & Chataway, Joanna, 2014. "Attitudes to vaccination: A critical review," Social Science & Medicine, Elsevier, vol. 112(C), pages 1-11.
    8. Polzin, Friedemann & von Flotow, Paschen & Klerkx, Laurens, 2016. "Addressing barriers to eco-innovation: Exploring the finance mobilisation functions of institutional innovation intermediaries," Technological Forecasting and Social Change, Elsevier, vol. 103(C), pages 34-46.
    9. Nelson, John P., 2023. "Differential “progressibility” in human know-how: A conceptual overview," Research Policy, Elsevier, vol. 52(2).
    10. Ohid Yaqub, 2018. "Variation in the dynamics and performance of industrial innovation: what can we learn from vaccines and HIV vaccines?," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 27(1), pages 173-187.
    11. Yaqub, Ohid, 2017. "Testing regimes in clinical trials: Evidence from four polio vaccine trajectories," Research Policy, Elsevier, vol. 46(2), pages 475-484.
    12. Matthew L. Wallace & Ismael Rafols, 2016. "Shaping the Agenda of a Grand Challenge: Institutional Mediation of Priorities in Avian Influenza Research," SPRU Working Paper Series 2016-02, SPRU - Science Policy Research Unit, University of Sussex Business School.

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