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Scaling up in Entrepreneurial Ecosystems: A comparative study of Entrepreneurial Ecosystems in Life Science

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  • Alvedalen, Janna

    (CIRCLE, Lund University)

  • Carlsson, Bo

    (Case Western Reserve University)

Abstract

Scaling-up is still underexplored in the Entrepreneurial Ecosystem literature. This paper presents a comparative analysis of five Entrepreneurial Ecosystems in Life Sciences in Sweden and the US, based on own data collection. It examines the factors that support or impede the scale-up process of firms in different geographical contexts. The paper outlines firm-specific and firm-external factors important to high-growth firms in Life Science and shows these factors differentiate across distinct geographical contexts. The study sheds light on key enablers and barriers to scaling-up in Entrepreneurial Ecosystems and the roles of different actors including growth ambition, technological expertise, management competence, business model alteration, funding, global firms, human capital, support organizations, local growth culture, hospitals and universities.

Suggested Citation

  • Alvedalen, Janna & Carlsson, Bo, 2021. "Scaling up in Entrepreneurial Ecosystems: A comparative study of Entrepreneurial Ecosystems in Life Science," Papers in Innovation Studies 2021/9, Lund University, CIRCLE - Centre for Innovation Research.
  • Handle: RePEc:hhs:lucirc:2021_009
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    1. Leo Sleuwaegen & Sander Ramboer, 2020. "Regional competitiveness and high growth firms in the EU: the creativity premium," Applied Economics, Taylor & Francis Journals, vol. 52(22), pages 2325-2338, May.
    2. Maryann Feldman & Ted D. Zoller, 2012. "Dealmakers in Place: Social Capital Connections in Regional Entrepreneurial Economies," Regional Studies, Taylor & Francis Journals, vol. 46(1), pages 23-37, June.
    3. David North & Robert Baldock & Farid Ullah, 2013. "Funding the growth of UK technology-based small firms since the financial crash: are there breakages in the finance escalator?," Venture Capital, Taylor & Francis Journals, vol. 15(3), pages 237-260, July.
    4. Ben Spigel, 2017. "The Relational Organization of Entrepreneurial Ecosystems," Entrepreneurship Theory and Practice, , vol. 41(1), pages 49-72, January.
    5. Roundy, Philip T., 2019. "Back from the brink: The revitalization of inactive entrepreneurial ecosystems," Journal of Business Venturing Insights, Elsevier, vol. 12(C).
    6. Magnus Henrekson & Dan Johansson, 2010. "Gazelles as job creators: a survey and interpretation of the evidence," Small Business Economics, Springer, vol. 35(2), pages 227-244, September.
    7. Ross Brown & Colin Mason, 2017. "Looking inside the spiky bits: a critical review and conceptualisation of entrepreneurial ecosystems," Small Business Economics, Springer, vol. 49(1), pages 11-30, June.
    8. Miozzo, Marcela & DiVito, Lori, 2016. "Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms," Research Policy, Elsevier, vol. 45(5), pages 964-986.
    9. Hellmann, Thomas F & Durufle, Gilles & Wilson, Karen, 2017. "From Start-up to Scale-up: Examining Public Policies for the Financing of High-Growth Ventures," CEPR Discussion Papers 12004, C.E.P.R. Discussion Papers.
    10. Daniel Isenberg & Vincent Onyemah, 2016. "Fostering Scaleup Ecosystems for Regional Economic Growth (Innovations Case Narrative: Manizales-Mas and Scale Up Milwaukee)," Innovations: Technology, Governance, Globalization, MIT Press, vol. 11(1-2), pages 60-79, Winter-Sp.
    11. Tom Kemeny & Maryann Feldman & Frank Ethridge & Ted Zoller, 2016. "The economic value of local social networks," Journal of Economic Geography, Oxford University Press, vol. 16(5), pages 1101-1122.
    12. Jue Wang & Philip Shapira, 2012. "Partnering with universities: a good choice for nanotechnology start-up firms?," Small Business Economics, Springer, vol. 38(2), pages 197-215, February.
    13. Colin Mason & Ross Brown, 2013. "Creating good public policy to support high-growth firms," Small Business Economics, Springer, vol. 40(2), pages 211-225, February.
    14. Sven-Olov Daunfeldt & Niklas Elert & Dan Johansson, 2014. "The Economic Contribution of High-Growth Firms: Do Policy Implications Depend on the Choice of Growth Indicator?," Journal of Industry, Competition and Trade, Springer, vol. 14(3), pages 337-365, September.
    15. Bernardo Batiz-Lazo & k Sarah Holland, 2004. "The Global Pharmaceutical Industry, 2004," General Economics and Teaching 0405002, University Library of Munich, Germany.
    16. Alex Coad, 2009. "The Growth of Firms," Books, Edward Elgar Publishing, number 13424.
    17. Zoltan J. Acs & Erik Stam & David B. Audretsch & Allan O’Connor, 2017. "The lineages of the entrepreneurial ecosystem approach," Small Business Economics, Springer, vol. 49(1), pages 1-10, June.
    18. Angelo Cavallo & Antonio Ghezzi & Raffaello Balocco, 2019. "Entrepreneurial ecosystem research: present debates and future directions," International Entrepreneurship and Management Journal, Springer, vol. 15(4), pages 1291-1321, December.
    19. Candida Brush & Linda F. Edelman & Tatiana Manolova & Friederike Welter, 2019. "A gendered look at entrepreneurship ecosystems," Small Business Economics, Springer, vol. 53(2), pages 393-408, August.
    20. Janna Alvedalen & Ron Boschma, 2017. "A critical review of entrepreneurial ecosystems research: towards a future research agenda," European Planning Studies, Taylor & Francis Journals, vol. 25(6), pages 887-903, June.
    21. Coad, Alex & Segarra, Agustí & Teruel, Mercedes, 2016. "Innovation and firm growth: Does firm age play a role?," Research Policy, Elsevier, vol. 45(2), pages 387-400.
    22. Neil Lee, 2014. "What holds back high-growth firms? Evidence from UK SMEs," Small Business Economics, Springer, vol. 43(1), pages 183-195, June.
    23. Massimo Colombo & Luca Grilli, 2007. "Funding Gaps? Access To Bank Loans By High-Tech Start-Ups," Small Business Economics, Springer, vol. 29(1), pages 25-46, June.
    24. Erik Stam, 2018. "Measuring Entrepreneurial Ecosystems," International Studies in Entrepreneurship, in: Allan O'Connor & Erik Stam & Fiona Sussan & David B. Audretsch (ed.), Entrepreneurial Ecosystems, pages 173-197, Springer.
    25. Cédric Schneider & Reinhilde Veugelers, 2010. "On young highly innovative companies: why they matter and how (not) to policy support them," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 19(4), pages 969-1007, August.
    26. Dubois, Anna & Gadde, Lars-Erik, 2002. "Systematic combining: an abductive approach to case research," Journal of Business Research, Elsevier, vol. 55(7), pages 553-560, July.
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    More about this item

    Keywords

    Entrepreneurial Ecosystem; scale-up; high-growth firms; Life Sciences; Sweden; U.S.;
    All these keywords.

    JEL classification:

    • L26 - Industrial Organization - - Firm Objectives, Organization, and Behavior - - - Entrepreneurship
    • M21 - Business Administration and Business Economics; Marketing; Accounting; Personnel Economics - - Business Economics - - - Business Economics
    • O33 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Technological Change: Choices and Consequences; Diffusion Processes

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