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Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France

Author

Listed:
  • Vincent Mangematin

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique, MTS - Management Technologique et Strategique - EESC-GEM Grenoble Ecole de Management)

  • Stéphane Lemarié

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique)

  • Jean-Pierre Boissin

    (CERAG - Centre d'études et de recherches appliquées à la gestion - UPMF - Université Pierre Mendès France - Grenoble 2 - CNRS - Centre National de la Recherche Scientifique)

  • David Catherine

    (MTS - Management Technologique et Strategique - EESC-GEM Grenoble Ecole de Management)

  • Frédéric Corolleur

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique)

  • Roger Coronini

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique)

  • Michel Trommetter

    (X-DEP-ECO - Département d'Économie de l'École Polytechnique - X - École polytechnique - IP Paris - Institut Polytechnique de Paris)

Abstract

Biotechnology is an emergent sector based on the creation of research-intensive Small and Medium Enterprises (SMEs). While some SMEs are growing, most of them remain small, even those set-up several years ago. What is the pattern of development of the biotech sector? What are the patterns of development of firms? Studies on the development of high-tech SMEs have focused on a business model, in which entrepreneurs rely on growth forecasts to persuade capital investors (business angels and venture capitalists) to invest in a radical innovation project. Firms aim for a world market to industrialise their innovation, and initial public offering (IPO) enables initial investors to make profits that offset risky initial investment. While this model is appealing, it is simply one of the possible models of biotechnology development. Some firms are not designed to experience exponential growth, and choose to target local markets. Moreover, not all firms have the ambition of being listed on the stock exchange. Based on an in-depth analysis of the business and development of 60 French biotech SMEs, this article identifies two business models. By defining the development trajectories of each of these models, it highlights the temporary nature of the emergent model.

Suggested Citation

  • Vincent Mangematin & Stéphane Lemarié & Jean-Pierre Boissin & David Catherine & Frédéric Corolleur & Roger Coronini & Michel Trommetter, 2003. "Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France," Post-Print hal-00422563, HAL.
    • Handle: RePEc:hal:journl:hal-00422563
    DOI: 10.1016/S0048-7333(02)00045-8
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    Citations

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    Cited by:

    1. Davenport, Sally, 2005. "Exploring the role of proximity in SME knowledge-acquisition," Research Policy, Elsevier, vol. 34(5), pages 683-701, June.
    2. Marina Dabić & Jane Maley & Leo-Paul Dana & Ivan Novak & Massimiliano M. Pellegrini & Andrea Caputo, 2020. "Pathways of SME internationalization: a bibliometric and systematic review," Small Business Economics, Springer, vol. 55(3), pages 705-725, October.
    3. Kalle Pajunen & Joonas Järvinen, 2018. "To survive or succeed? An analysis of biotechnology firms," Small Business Economics, Springer, vol. 51(3), pages 757-771, October.
    4. Corolleur, Catherine D. F. & Carrere, M. & Mangematin, V., 2004. "Turning scientific and technological human capital into economic capital: the experience of biotech start-ups in France," Research Policy, Elsevier, vol. 33(4), pages 631-642, May.
    5. Jane Marceau, 2007. "Bringing science to life in Australia: the need for a new approach in human health biotechnology policy," The Journal of Technology Transfer, Springer, vol. 32(4), pages 303-327, August.
    6. Eduardo Picanço Cruz & Roberto Pessoa QueirozFalcão & Rafael Cuba Mancebo, 2020. "Market orientation and strategic decisions on immigrant and ethnic small firms," Journal of International Entrepreneurship, Springer, vol. 18(2), pages 227-255, June.
    7. Andrea Setti, 2020. "Linking science-based firms with performance factors: An integrative systematic review of literature," International Journal of Research in Business and Social Science (2147-4478), Center for the Strategic Studies in Business and Finance, vol. 9(2), pages 09-42, March.
    8. Marina van Geenhuizen & Peter Nijkamp, 2011. "Knowledge Virtualization and Local Connectedness among Smart High-tech Companies," Tinbergen Institute Discussion Papers 11-119/3, Tinbergen Institute.
    9. Miozzo, Marcela & DiVito, Lori, 2016. "Growing fast or slow?: Understanding the variety of paths and the speed of early growth of entrepreneurial science-based firms," Research Policy, Elsevier, vol. 45(5), pages 964-986.
    10. Gerard George & Adam J. Bock, 2011. "The Business Model in Practice and its Implications for Entrepreneurship Research," Entrepreneurship Theory and Practice, , vol. 35(1), pages 83-111, January.
    11. Riccardo Fini & Rosa Grimaldi & Gian Luca Marzocchi & Maurizio Sobrero, 2012. "The Determinants of Corporate Entrepreneurial Intention within Small and Newly Established Firms," Entrepreneurship Theory and Practice, , vol. 36(2), pages 387-414, March.
    12. Marina Geenhuizen, 2007. "Modelling dynamics of knowledge networks and local connectedness: a case study of urban high-tech companies in The Netherlands," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 41(4), pages 813-833, December.
    13. Corine Genet & Khalid Errabi & Caroline Gauthier, 2012. "Which Model of Technology Transfer for Nanotechnology? A Comparison with Biotech and Microelectronics," Post-Print hal-00749152, HAL.
    14. Jose-Luis Hervas-Oliver, 2011. "Social Networks across Spatial Agglomerations: the Paradox of High-Tech Clusters. A Critical Revision of Clusters," ERSA conference papers ersa11p779, European Regional Science Association.
    15. Emmanuelle Dubocage & Géraldine Galindo, 2008. "Le rôle des capital-risqueurs dans l'isomorphisme stratégique des "biotechs"," Revue Finance Contrôle Stratégie, revues.org, vol. 11(4), pages 5-30, December.
    16. Adam Jabłoński & Marek Jabłoński, 2019. "Trust as a Key Factor in Shaping the Social Business Model of Water Supply Companies," Sustainability, MDPI, vol. 11(20), pages 1-48, October.
    17. John Hagedoorn & Boris Lokshin & Stéphane Malo, 2018. "Alliances and the innovation performance of corporate and public research spin-off firms," Small Business Economics, Springer, vol. 50(4), pages 763-781, April.
    18. David Catherine & Frédéric Corolleur & Myriam Carrère & Vincent Mangematin, 2004. "Turning scientific and technological human capital into economic capital: the experience of biotech start-ups in France," Post-Print hal-00422583, HAL.
    19. N. Moray & B. Clarysse, 2005. "Institutional Origin and Resource Endowments to Science-Based Entrepreneurial Firms: A European Exploration," Working Papers of Faculty of Economics and Business Administration, Ghent University, Belgium 05/296, Ghent University, Faculty of Economics and Business Administration.
    20. von Delft, Stephan & Zhao, Yang, 2021. "Business models in process industries: Emerging trends and future research," Technovation, Elsevier, vol. 105(C).

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