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Vaccination under pessimistic expectations in clinical trials and immunization campaigns

Author

Listed:
  • Johanna Etner

    (EconomiX - EconomiX - UPN - Université Paris Nanterre - CNRS - Centre National de la Recherche Scientifique)

  • Josselin Thuilliez

    (CES - Centre d'économie de la Sorbonne - UP1 - Université Paris 1 Panthéon-Sorbonne - CNRS - Centre National de la Recherche Scientifique)

  • Hippolyte d'Albis

    (PSE - Paris School of Economics - UP1 - Université Paris 1 Panthéon-Sorbonne - ENS-PSL - École normale supérieure - Paris - PSL - Université Paris Sciences et Lettres - EHESS - École des hautes études en sciences sociales - ENPC - École nationale des ponts et chaussées - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, PJSE - Paris Jourdan Sciences Economiques - UP1 - Université Paris 1 Panthéon-Sorbonne - ENS-PSL - École normale supérieure - Paris - PSL - Université Paris Sciences et Lettres - EHESS - École des hautes études en sciences sociales - ENPC - École nationale des ponts et chaussées - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement)

Abstract

We provide one of the first formalizations of a vaccination campaign in a decisiontheoretic framework. We analyse a model where an ambiguity-averse individual must decide how much effort to invest into prevention in the context of a rampant disease. We study how ambiguity aversion affects the effort and the estimation of the vaccine efficacy in clinical trials and immunization campaigns. We find that the behaviours of individuals participating in a clinical trial differ from individuals not participating. Individuals who are more optimistic toward vaccination participate more in trials. Their behaviours and efforts are also affected. As a result, because vaccine efficacy depends on unobserved behaviours and efforts, the biological effect of the vaccine becomes difficult to evaluate. During the scale-up phase of a vaccination campaign, provided that vaccine efficacy is established, we show that vaccine hesitancy may still be rational.

Suggested Citation

  • Johanna Etner & Josselin Thuilliez & Hippolyte d'Albis, 2022. "Vaccination under pessimistic expectations in clinical trials and immunization campaigns," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) halshs-03763363, HAL.
    • Handle: RePEc:hal:cesptp:halshs-03763363
    Note: View the original document on HAL open archive server: https://shs.hal.science/halshs-03763363v1
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    Cited by:

    1. Thuilliez, Josselin & Touré, Nouhoum, 2024. "Opinions and vaccination during an epidemic," Journal of Mathematical Economics, Elsevier, vol. 111(C).
    2. Josselin Thuilliez & Nouhoum Touré, 2024. "Opinions and vaccination during an epidemic," Post-Print hal-04490900, HAL.
    3. Rabah Amir & Raouf Boucekkine, 2023. "Epidemics, vaccines, and health policy," Journal of Public Economic Theory, Association for Public Economic Theory, vol. 25(6), pages 1143-1148, December.
    4. Josselin Thuilliez & Nouhoum Touré, 2024. "Opinions and vaccination during an epidemic," Université Paris1 Panthéon-Sorbonne (Post-Print and Working Papers) hal-04490900, HAL.

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    Keywords

    Decision Theory; Vaccination; Clinical Trials; Immunization Campaigns Decision Theory; Immunization Campaigns;
    All these keywords.

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