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Predictive Genetic Testing for Alzheimer's Disease: Impact upon Risk Perception

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  • Theresa M. Marteau
  • Scott Roberts
  • Susan LaRusse
  • Robert C. Green

Abstract

The aim of this study was to determine the impact on risk perceptions of disclosing genetic test results used to estimate the risk of Alzheimer's disease (AD). Adult children (n= 149) of people with AD were randomized to one of two groups—Intervention group: lifetime risk estimates of AD based on age, gender, family history, and Apolipoprotein E (APOE) genotype; Control group: lifetime risk estimates of AD based on the same risk factors excluding APOE genotype. Perceptions of personal risk (PPR) for AD were assessed six weeks after risk assessments. PPR were correlated with actual lifetime risk estimates (r= 0.501; p

Suggested Citation

  • Theresa M. Marteau & Scott Roberts & Susan LaRusse & Robert C. Green, 2005. "Predictive Genetic Testing for Alzheimer's Disease: Impact upon Risk Perception," Risk Analysis, John Wiley & Sons, vol. 25(2), pages 397-404, April.
    • Handle: RePEc:wly:riskan:v:25:y:2005:i:2:p:397-404
    DOI: 10.1111/j.1539-6924.2005.00598.x
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    References listed on IDEAS

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    1. Senior, Victoria & Marteau, Theresa M. & Peters, Timothy J., 1999. "Will genetic testing for predisposition for disease result in fatalism? A qualitative study of parents responses to neonatal screening for familial hypercholesterolaemia," Social Science & Medicine, Elsevier, vol. 48(12), pages 1857-1860, June.
    2. Francis S. Collins & Eric D. Green & Alan E. Guttmacher & Mark S. Guyer, 2003. "A vision for the future of genomics research," Nature, Nature, vol. 422(6934), pages 835-847, April.
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    Cited by:

    1. Amalia R. Miller & Catherine Tucker, 2018. "Privacy Protection, Personalized Medicine, and Genetic Testing," Management Science, INFORMS, vol. 64(10), pages 4648-4668, October.

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