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The EPA Health Risk Assessment of Methylcyclopentadienyl Manganese Tricarbonyl (MMT)

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  • J. Michael Davis
  • Annie M. Jarabek
  • David T. Mage
  • Judith A. Graham

Abstract

This paper describes the U.S. Environmental Protection Agency's assessment of potential health risks associated with the possible widespread use of a manganese (Mn)‐based fuel additive, methylcyclopentadienyl manganese tricarbonyl (MMT). This assessment was significant in several respects and may be instructive in identifying certain methodological issues of general relevance to risk assessment. A major feature of the inhalation health risk assessment was the derivation of Mn inhalation reference concentration (RfC) estimates using various statistical approaches, including benchmark dose and Bayesian analyses. The exposure assessment component used data from the Particle Total Exposure Assessment Methodology (PTEAM) study and other sources to estimate personal exposure levels of particulate Mn attributable to the permitted use of MMT in leaded gasoline in Riverside, CA, at the time of the PTEAM study; on this basis it was then possible to predict a distribution of possible future exposure levels associated with the use of MMT in all unleaded gasoline. Qualitative as well as quantitative aspects of the risk characterization are summarized, along with inherent uncertainties due to data limitations.

Suggested Citation

  • J. Michael Davis & Annie M. Jarabek & David T. Mage & Judith A. Graham, 1998. "The EPA Health Risk Assessment of Methylcyclopentadienyl Manganese Tricarbonyl (MMT)," Risk Analysis, John Wiley & Sons, vol. 18(1), pages 57-70, February.
    • Handle: RePEc:wly:riskan:v:18:y:1998:i:1:p:57-70
    DOI: 10.1111/j.1539-6924.1998.tb00916.x
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    References listed on IDEAS

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    1. Lance A. Wallace & Naihua Duan & Robert Ziegenfus, 1994. "Can Long‐Term Exposure Distributions Be Predicted from Short‐Term Measurements?," Risk Analysis, John Wiley & Sons, vol. 14(1), pages 75-85, February.
    2. Carole A. Kimmel & David W. Gaylor, 1988. "Issues in Qualitative and Quantitative Risk Analysis for Developmental Toxicology," Risk Analysis, John Wiley & Sons, vol. 8(1), pages 15-20, March.
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    1. Harvey J. Clewell & Gregory A. Lawrence & Donald B. Calne & Kenny S. Crump, 2003. "Determination of an Occupational Exposure Guideline for Manganese Using the Benchmark Method," Risk Analysis, John Wiley & Sons, vol. 23(5), pages 1031-1046, October.

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