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Analysis of microtubule dynamics using growth curve models

Author

Listed:
  • S. Rao Jammalamadaka
  • Md. Aleemuddin Siddiqi
  • Kaushik Ghosh

Abstract

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics.

Suggested Citation

  • S. Rao Jammalamadaka & Md. Aleemuddin Siddiqi & Kaushik Ghosh, 2009. "Analysis of microtubule dynamics using growth curve models," Journal of Applied Statistics, Taylor & Francis Journals, vol. 36(6), pages 621-631.
    • Handle: RePEc:taf:japsta:v:36:y:2009:i:6:p:621-631
    DOI: 10.1080/02664760802479131
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    References listed on IDEAS

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    1. Gareth M. James & Trevor J. Hastie, 2001. "Functional linear discriminant analysis for irregularly sampled curves," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(3), pages 533-550.
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