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Smoothing spline estimation of generalised varying-coefficient mixed model

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  • Yiqiang Lu
  • Riquan Zhang

Abstract

The generalised varying-coefficient model with longitudinal data faces a challenge that the data are correlated, as multiple observations are measured from each individual. In this article we consider the generalised varying-coefficient mixed model (GVCMM) which uses a varying-coefficient model to fit mean functions, while accounting for overdispersion and correlation by adding random effects. Smoothing splines are used to estimate the smooth but arbitrary nonparametric coefficient functions. The usually intractable integration involved in evaluating the quasi-likelihood function is approximated by the Laplace method. This suggests that the GVCMM can be approximately represented by a generalised linear mixed model. Hence, the smoothing parameters and the variance components can be estimated by using the restricted maximum log-likelihood (REML) approach, where the smoothing parameters are treated as an extra variance component vector. We illustrate the performance of the proposed method through some simulation and an application to a real data set.

Suggested Citation

  • Yiqiang Lu & Riquan Zhang, 2009. "Smoothing spline estimation of generalised varying-coefficient mixed model," Journal of Nonparametric Statistics, Taylor & Francis Journals, vol. 21(7), pages 815-825.
    • Handle: RePEc:taf:gnstxx:v:21:y:2009:i:7:p:815-825
    DOI: 10.1080/10485250903151078
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    1. Cai, Zongwu & Fan, Jianqing & Yao, Qiwei, 2000. "Functional-coefficient regression models for nonlinear time series," LSE Research Online Documents on Economics 6314, London School of Economics and Political Science, LSE Library.
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    3. Chiang C-T. & Rice J. A & Wu C. O, 2001. "Smoothing Spline Estimation for Varying Coefficient Models With Repeatedly Measured Dependent Variables," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 605-619, June.
    4. Jeffrey S. Morris & Raymond J. Carroll, 2006. "Wavelet‐based functional mixed models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(2), pages 179-199, April.
    5. X. Lin & D. Zhang, 1999. "Inference in generalized additive mixed modelsby using smoothing splines," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 61(2), pages 381-400, April.
    6. Jianhua Z. Huang, 2002. "Varying-coefficient models and basis function approximations for the analysis of repeated measurements," Biometrika, Biometrika Trust, vol. 89(1), pages 111-128, March.
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    Cited by:

    1. Jeong, Seonghyun & Park, Minjae & Park, Taeyoung, 2017. "Analysis of binary longitudinal data with time-varying effects," Computational Statistics & Data Analysis, Elsevier, vol. 112(C), pages 145-153.

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