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Skeletonization for isocentre selection in Gamma Knife® Perfexion™

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  • Evgueniia Doudareva
  • Kimia Ghobadi
  • Dionne Aleman
  • Mark Ruschin
  • David Jaffray

Abstract

Gamma Knife® Perfexion™ (PFX) is used for delivering radiosurgery plans to treat lesions and tumours in the brain by means of selectively ionizing the tissue with high-energy beams of radiation. An important component of designing PFX treatments is the selection of points in the target structure at which to focus the radiation, called isocentres. This study applies skeletonization methods to select such isocentres. Our skeletonization technique identifies clusters of each target structure’s skeleton using distance coding methods. A user-defined number of isocentre locations are chosen from the skeletal clusters. The isocentres resulting from this approach are used as input to a sector duration optimization model that determines the optimal shot shapes and intensities for the radiation deposited at each isocentre. The results for seven clinical cases are presented. For each case, target structure dose and conformity meet clinical radiosurgery guidelines, while brainstem dose is kept to acceptable levels and other healthy organs are also spared. Copyright Sociedad de Estadística e Investigación Operativa 2015

Suggested Citation

  • Evgueniia Doudareva & Kimia Ghobadi & Dionne Aleman & Mark Ruschin & David Jaffray, 2015. "Skeletonization for isocentre selection in Gamma Knife® Perfexion™," TOP: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 23(2), pages 369-385, July.
    • Handle: RePEc:spr:topjnl:v:23:y:2015:i:2:p:369-385
    DOI: 10.1007/s11750-014-0344-x
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    References listed on IDEAS

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    1. Jie Wang, 2000. "Medial Axis and Optimal Locations for Min-Max Sphere Packing," Journal of Combinatorial Optimization, Springer, vol. 4(4), pages 487-503, December.
    2. Jie Wang, 1999. "Packing of Unequal Spheres and Automated Radiosurgical Treatment Planning," Journal of Combinatorial Optimization, Springer, vol. 3(4), pages 453-463, December.
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    Cited by:

    1. Oylum S¸eker & Mucahit Cevik & Merve Bodur & Young Lee & Mark Ruschin, 2023. "A Multiobjective Approach for Sector Duration Optimization in Stereotactic Radiosurgery Treatment Planning," INFORMS Journal on Computing, INFORMS, vol. 35(1), pages 248-264, January.

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