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A Generalized Interrupted Time Series Model for Assessing Complex Health Care Interventions

Author

Listed:
  • Maricela Cruz

    (Kaiser Permanente Washington Health Research Institute)

  • Hernando Ombao

    (King Abdullah University of Science and Technology)

  • Daniel L. Gillen

    (University of California Irvine)

Abstract

Assessing the impact of complex interventions on measurable health outcomes is a growing concern in health care and health policy. Interrupted time series (ITS) designs borrow from traditional case-crossover designs and function as quasi-experimental methodology able to retrospectively analyze the impact of an intervention. Statistical models used to analyze ITS designs primarily focus on continuous-valued outcomes. We propose the “Generalized Robust ITS" (GRITS) model appropriate for outcomes whose underlying distribution belongs to the exponential family of distributions, thereby expanding the available methodology to adequately model binary and count responses. GRITS formally implements a test for the existence of a change point in discrete ITS. The methodology proposed is able to test for the existence of and estimate the change point, borrow information across units in multi-unit settings, and test for differences in the mean function and correlation pre- and post-intervention. The methodology is illustrated by analyzing patient falls from a hospital that implemented and evaluated a new care delivery model in multiple units.

Suggested Citation

  • Maricela Cruz & Hernando Ombao & Daniel L. Gillen, 2022. "A Generalized Interrupted Time Series Model for Assessing Complex Health Care Interventions," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 14(3), pages 582-610, December.
    • Handle: RePEc:spr:stabio:v:14:y:2022:i:3:d:10.1007_s12561-022-09346-6
    DOI: 10.1007/s12561-022-09346-6
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    References listed on IDEAS

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    1. Ariel Linden, 2015. "Conducting interrupted time-series analysis for single- and multiple-group comparisons," Stata Journal, StataCorp LP, vol. 15(2), pages 480-500, June.
    2. Wei Pan, 2001. "Akaike's Information Criterion in Generalized Estimating Equations," Biometrics, The International Biometric Society, vol. 57(1), pages 120-125, March.
    3. Wolfgang Härdle & Joel Horowitz & Jens‐Peter Kreiss, 2003. "Bootstrap Methods for Time Series," International Statistical Review, International Statistical Institute, vol. 71(2), pages 435-459, August.
    4. Marie Hušková & Claudia Kirch, 2008. "Bootstrapping confidence intervals for the change‐point of time series," Journal of Time Series Analysis, Wiley Blackwell, vol. 29(6), pages 947-972, November.
    5. West, S.G. & Duan, N. & Pequegnat, W. & Gaist, P. & Des Jarlais, D.C. & Holtgrave, D. & Szapocznik, J. & Fishbein, M. & Rapkin, B. & Clatts, M. & Mullen, P.D., 2008. "Alternatives to the randomized controlled trial," American Journal of Public Health, American Public Health Association, vol. 98(8), pages 1359-1366.
    6. Alan Agresti & Euijung Ryu, 2010. "Pseudo-score confidence intervals for parameters in discrete statistical models," Biometrika, Biometrika Trust, vol. 97(1), pages 215-222.
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