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Evaluating Health Related Quality of Life in Older People at Risk of Osteoporotic Fracture: A Head-to-Head Comparison of the EQ-5D-5L and AQoL-6D

Author

Listed:
  • Lei Si

    (UNSW Sydney
    UNSW Sydney)

  • Liudan Tu

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Ya Xie

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Gang Chen

    (Monash University)

  • Mickaël Hiligsmann

    (Maastricht University)

  • Mingcan Yang

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Yanli Zhang

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Xi Zhang

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Yutong Jiang

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Qiujing Wei

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Jieruo Gu

    (Third Affiliated Hospital of Sun Yat-Sen University)

  • Andrew J. Palmer

    (University of Tasmania
    The University of Melbourne)

Abstract

We aimed to conduct a head-to-head comparison of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) and the Assessment of Quality of Life-6D (AQoL-6D) in measuring health-related quality of life (HRQoL) of older people at risk of osteoporotic fracture. Participants (n = 291) were recruited from the Third Affiliated Hospital of Sun Yat-Sen University. Study participants were asked to complete the EQ-5D-5L and the AQoL-6D and the results were converted to health-state utilities (HSUs) using population-specific scoring algorithms. The agreement among HSUs was evaluated using the intraclass correlation coefficient and illustrated using Bland–Altman plots. The minimally important difference (MID) for the EQ-5D and AQoL was set at 0.074 and 0.06. Information on socio-demographic background, socio-economic status and clinical risk factors in FRAX® was collected. Nonparametric statistics were used to explore the known-group validity measured by fracture risk. Mean (median) EQ-5D-5L and AQoL-6D HSUs were 0.73(0.83) and 0.74(0.79) for the study population. The EQ-5D-5L and the AQoL-6D HSUs strongly agreed and the HSU difference reached the MID level in both instruments. While a decreasing trend of AQoL-6D utilities was observed with worsening bone mineral density, EQ-5D-5L HSUs were similar in individuals with normal and osteopenic bone mineral densities. The AQoL-6D was also effective for measuring difference in independent living, relationships, mental health, coping and pain. Both instruments showed good known-group validity. The EQ-5D-5L and AQoL-6D are all valid measures for older people at risk of osteoporotic fracture.

Suggested Citation

  • Lei Si & Liudan Tu & Ya Xie & Gang Chen & Mickaël Hiligsmann & Mingcan Yang & Yanli Zhang & Xi Zhang & Yutong Jiang & Qiujing Wei & Jieruo Gu & Andrew J. Palmer, 2022. "Evaluating Health Related Quality of Life in Older People at Risk of Osteoporotic Fracture: A Head-to-Head Comparison of the EQ-5D-5L and AQoL-6D," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 160(2), pages 809-824, April.
    • Handle: RePEc:spr:soinre:v:160:y:2022:i:2:d:10.1007_s11205-020-02414-8
    DOI: 10.1007/s11205-020-02414-8
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    References listed on IDEAS

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    1. Nancy J. Devlin & Richard Brooks, 2017. "EQ-5D and the EuroQol Group: Past, Present and Future," Applied Health Economics and Health Policy, Springer, vol. 15(2), pages 127-137, April.
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    4. Julie A. Campbell & Andrew J. Palmer & Alison Venn & Melanie Sharman & Petr Otahal & Amanda Neil, 2016. "A Head-to-Head Comparison of the EQ-5D-5L and AQoL-8D Multi-Attribute Utility Instruments in Patients Who Have Previously Undergone Bariatric Surgery," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 9(4), pages 311-322, August.
    5. Jeff Richardson & Angelo Iezzi & Munir Khan & Aimee Maxwell, 2014. "Validity and Reliability of the Assessment of Quality of Life (AQoL)-8D Multi-Attribute Utility Instrument," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 7(1), pages 85-96, March.
    6. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
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