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Health-Economic Analyses of Diagnostics: Guidance on Design and Reporting

Author

Listed:
  • Simon Pol

    (University of Groningen, University Medical Center Groningen)

  • Paula Rojas Garcia

    (University of La Rioja)

  • Fernando Antoñanzas Villar

    (University of La Rioja)

  • Maarten J. Postma

    (University of Groningen, University Medical Center Groningen
    University of Groningen)

  • Antoinette D. I. Asselt

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

Abstract

Cost-effectiveness analyses (CEAs) can be used to assess the value of diagnostics in clinical practice. Due to the introduction of the European in vitro diagnostic and medical devices regulations, more clinical data on new diagnostics may become available, which may improve the interest and feasibility of performing CEAs. We present eight recommendations on the reporting and design of CEAs of diagnostics. The symptoms patients experience, the clinical setting, locations of test sampling and analysis, and diagnostic algorithms should be clearly reported. The used time horizon should reflect the time horizon used to model the treatment after the diagnostic pathway. Quality-adjusted life-years (QALYs) or disability-adjusted life-years (DALYs) should be used as the clinical outcomes but may be combined with other relevant outcomes, such as real options value. If the number of tests using the same equipment can vary, the economy of scale should be considered. An understandable graphical representation of the various diagnostic algorithms should be provided to understand the results, such as an efficiency frontier. Finally, the budget impact and affordability should be considered. These recommendations can be used in addition to other, more general, recommendations, such as the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) or the reference case for economic evaluation by the international decision support initiative.

Suggested Citation

  • Simon Pol & Paula Rojas Garcia & Fernando Antoñanzas Villar & Maarten J. Postma & Antoinette D. I. Asselt, 2021. "Health-Economic Analyses of Diagnostics: Guidance on Design and Reporting," PharmacoEconomics, Springer, vol. 39(12), pages 1355-1363, December.
    • Handle: RePEc:spr:pharme:v:39:y:2021:i:12:d:10.1007_s40273-021-01104-8
    DOI: 10.1007/s40273-021-01104-8
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    References listed on IDEAS

    as
    1. Simon van der Pol & Paula Rojas Garcia & Maarten J. Postma & Fernando Antoñanzas Villar & Antoinette D. I. Asselt, 2021. "Economic Analyses of Respiratory Tract Infection Diagnostics: A Systematic Review," PharmacoEconomics, Springer, vol. 39(12), pages 1411-1427, December.
    2. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
    3. Kroneman, Madelon W. & Maarse, Hans & Zee, Jouke van der, 2006. "Direct access in primary care and patient satisfaction: A European study," Health Policy, Elsevier, vol. 76(1), pages 72-79, March.
    4. Annalisa Belloni & David Morgan & Valérie Paris, 2016. "Pharmaceutical Expenditure And Policies: Past Trends And Future Challenges," OECD Health Working Papers 87, OECD Publishing.
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