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Overview and Use of Tools for Selecting Modelling Techniques in Health Economic Studies

Author

Listed:
  • Huajie Jin

    (Institute of Psychiatry, Psychology and Neuroscience at King’s College London, The David Goldberg Centre)

  • Stewart Robinson

    (Loughborough University)

  • Wenru Shang

    (Fudan University)

  • Evanthia Achilla

    (IQVIA)

  • David Aceituno

    (Institute of Psychiatry, Psychology and Neuroscience at King’s College London, The David Goldberg Centre)

  • Sarah Byford

    (Institute of Psychiatry, Psychology and Neuroscience at King’s College London, The David Goldberg Centre)

Abstract

The availability and use of tools to guide the choice of modelling technique are not well understood. Our study aims to review existing tools and explore the use of those tools in health economic models. Two reviews and one case study were conducted. Review 1 aimed to identify tools based on expert opinion and citation searching and explore the value of the tools for health economic models. Review 2, based on citation searching, aimed to describe how those tools have been used in health economic models. Both reviews were conducted using Web of Science and Scopus. Two independent reviewers selected studies for inclusion. A case study, focused on economic evaluations of antipsychotic medication in schizophrenia, was conducted to compare the modelling techniques used by existing models with modelling techniques recommended by identified tools. Seven tools were identified, of which the revised Brennan’s toolkit, was assessed to be the most appropriate for health economic models. The seven tools were cited 126 times in publications reporting health economic models. Only 17 of these (13.5%) reported that they used the tool(s) to guide the choice of modelling technique. Application of these tools suggested discrete event simulation is most appropriate for modelling antipsychotic medication in schizophrenia, but discrete event simulation was only used by 17% of existing models. There is considerable inconsistency between the modelling techniques used by existing models and modelling techniques recommended by tools. It is recommended that for future modelling studies the choice of modelling technique should be justified, this can be achieved by the application of model selection tools, such as the revised Brennan’s toolkit. Future research is required to explore the barriers to using model selection tools in health economic models and to update existing tools and make them easier to use.

Suggested Citation

  • Huajie Jin & Stewart Robinson & Wenru Shang & Evanthia Achilla & David Aceituno & Sarah Byford, 2021. "Overview and Use of Tools for Selecting Modelling Techniques in Health Economic Studies," PharmacoEconomics, Springer, vol. 39(7), pages 757-770, July.
    • Handle: RePEc:spr:pharme:v:39:y:2021:i:7:d:10.1007_s40273-021-01038-1
    DOI: 10.1007/s40273-021-01038-1
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Alan Brennan & Stephen E. Chick & Ruth Davies, 2006. "A taxonomy of model structures for economic evaluation of health technologies," Health Economics, John Wiley & Sons, Ltd., vol. 15(12), pages 1295-1310, December.
    3. Ash Bullement & Holly L. Cranmer & Gemma E. Shields, 2019. "A Review of Recent Decision-Analytic Models Used to Evaluate the Economic Value of Cancer Treatments," Applied Health Economics and Health Policy, Springer, vol. 17(6), pages 771-780, December.
    4. Huajie Jin & Paul Tappenden & Stewart Robinson & Evanthia Achilla & David Aceituno & Sarah Byford, 2020. "Systematic review of the methods of health economic models assessing antipsychotic medication for schizophrenia," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-18, July.
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    Cited by:

    1. Penny R. Breeze & Hazel Squires & Kate Ennis & Petra Meier & Kate Hayes & Nik Lomax & Alan Shiell & Frank Kee & Frank de Vocht & Martin O’Flaherty & Nigel Gilbert & Robin Purshouse & Stewart Robinson , 2023. "Guidance on the use of complex systems models for economic evaluations of public health interventions," Health Economics, John Wiley & Sons, Ltd., vol. 32(7), pages 1603-1625, July.

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