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An additive hazards cure model with informative interval censoring

Author

Listed:
  • Shuying Wang

    (Changchun University of Technology)

  • Chunjie Wang

    (Changchun University of Technology)

  • Jianguo Sun

    (Jilin University)

Abstract

The existence of a cured subgroup happens quite often in survival studies and many authors considered this under various situations (Farewell in Biometrics 38:1041–1046, 1982; Kuk and Chen in Biometrika 79:531–541, 1992; Lam and Xue in Biometrika 92:573–586, 2005; Zhou et al. in J Comput Graph Stat 27:48–58, 2018). In this paper, we discuss the situation where only interval-censored data are available and furthermore, the censoring may be informative, for which there does not seem to exist an established estimation procedure. For the analysis, we present a three component model consisting of a logistic model for describing the cure rate, an additive hazards model for the failure time of interest and a nonhomogeneous Poisson model for the observation process. For estimation, we propose a sieve maximum likelihood estimation procedure and the asymptotic properties of the resulting estimators are established. Furthermore, an EM algorithm is developed for the implementation of the proposed estimation approach, and extensive simulation studies are conducted and suggest that the proposed method works well for practical situations. Also the approach is applied to a cardiac allograft vasculopathy study that motivated this investigation.

Suggested Citation

  • Shuying Wang & Chunjie Wang & Jianguo Sun, 2021. "An additive hazards cure model with informative interval censoring," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(2), pages 244-268, April.
    • Handle: RePEc:spr:lifeda:v:27:y:2021:i:2:d:10.1007_s10985-021-09515-7
    DOI: 10.1007/s10985-021-09515-7
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    References listed on IDEAS

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    1. Wang, Shuying & Wang, Chunjie & Wang, Peijie & Sun, Jianguo, 2020. "Estimation of the additive hazards model with case K interval-censored failure time data in the presence of informative censoring," Computational Statistics & Data Analysis, Elsevier, vol. 144(C).
    2. C.-Y. Huang & J. Qin & M.-C. Wang, 2010. "Semiparametric Analysis for Recurrent Event Data with Time-Dependent Covariates and Informative Censoring," Biometrics, The International Biometric Society, vol. 66(1), pages 39-49, March.
    3. Chen, Xiaohong & Fan, Yanqin & Tsyrennikov, Viktor, 2006. "Efficient Estimation of Semiparametric Multivariate Copula Models," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1228-1240, September.
    4. Peijie Wang & Hui Zhao & Jianguo Sun, 2016. "Regression analysis of case K interval‐censored failure time data in the presence of informative censoring," Biometrics, The International Biometric Society, vol. 72(4), pages 1103-1112, December.
    5. Hu, Tao & Xiang, Liming, 2013. "Efficient estimation for semiparametric cure models with interval-censored data," Journal of Multivariate Analysis, Elsevier, vol. 121(C), pages 139-151.
    6. Liu, Hao & Shen, Yu, 2009. "A Semiparametric Regression Cure Model for Interval-Censored Data," Journal of the American Statistical Association, American Statistical Association, vol. 104(487), pages 1168-1178.
    7. Ling Ma & Tao Hu & Jianguo Sun, 2015. "Sieve maximum likelihood regression analysis of dependent current status data," Biometrika, Biometrika Trust, vol. 102(3), pages 731-738.
    8. Li, Shuwei & Hu, Tao & Wang, Peijie & Sun, Jianguo, 2017. "Regression analysis of current status data in the presence of dependent censoring with applications to tumorigenicity experiments," Computational Statistics & Data Analysis, Elsevier, vol. 110(C), pages 75-86.
    9. Xu, Linzhi & Zhang, Jiajia, 2010. "Multiple imputation method for the semiparametric accelerated failure time mixture cure model," Computational Statistics & Data Analysis, Elsevier, vol. 54(7), pages 1808-1816, July.
    10. K. F. Lam & Hongqi Xue, 2005. "A semiparametric regression cure model with current status data," Biometrika, Biometrika Trust, vol. 92(3), pages 573-586, September.
    11. Li, Shuwei & Hu, Tao & Zhao, Xingqiu & Sun, Jianguo, 2019. "A class of semiparametric transformation cure models for interval-censored failure time data," Computational Statistics & Data Analysis, Elsevier, vol. 133(C), pages 153-165.
    12. Yu, Binbing & Peng, Yingwei, 2008. "Mixture cure models for multivariate survival data," Computational Statistics & Data Analysis, Elsevier, vol. 52(3), pages 1524-1532, January.
    13. Wang, Shuying & Wang, Chunjie & Wang, Peijie & Sun, Jianguo, 2018. "Semiparametric analysis of the additive hazards model with informatively interval-censored failure time data," Computational Statistics & Data Analysis, Elsevier, vol. 125(C), pages 1-9.
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