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Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion

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  • Yuan Wu

    (Duke University)

  • Christina D. Chambers

    (University of California
    University of California)

  • Ronghui Xu

    (University of California
    University of California)

Abstract

This work was motivated by observational studies in pregnancy with spontaneous abortion (SAB) as outcome. Clearly some women experience the SAB event but the rest do not. In addition, the data are left truncated due to the way pregnant women are recruited into these studies. For those women who do experience SAB, their exact event times are sometimes unknown. Finally, a small percentage of the women are lost to follow-up during their pregnancy. All these give rise to data that are left truncated, partly interval and right-censored, and with a clearly defined cured portion. We consider the non-mixture Cox regression cure rate model and adopt the semiparametric spline-based sieve maximum likelihood approach to analyze such data. Using modern empirical process theory we show that both the parametric and the nonparametric parts of the sieve estimator are consistent, and we establish the asymptotic normality for both parts. Simulation studies are conducted to establish the finite sample performance. Finally, we apply our method to a database of observational studies on spontaneous abortion.

Suggested Citation

  • Yuan Wu & Christina D. Chambers & Ronghui Xu, 2019. "Semiparametric sieve maximum likelihood estimation under cure model with partly interval censored and left truncated data for application to spontaneous abortion," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(3), pages 507-528, July.
    • Handle: RePEc:spr:lifeda:v:25:y:2019:i:3:d:10.1007_s10985-018-9445-4
    DOI: 10.1007/s10985-018-9445-4
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    References listed on IDEAS

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    Cited by:

    1. Xiaoguang Wang & Ziwen Wang, 2021. "EM algorithm for the additive risk mixture cure model with interval-censored data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(1), pages 91-130, January.
    2. Pao-sheng Shen & Yingwei Peng & Hsin-Jen Chen & Chyong-Mei Chen, 2022. "Maximum likelihood estimation for length-biased and interval-censored data with a nonsusceptible fraction," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(1), pages 68-88, January.

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