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Modeling marginal features in studies of recurrent events in the presence of a terminal event

Author

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  • Per Kragh Andersen

    (University of Copenhagen)

  • Jules Angst

    (University of Zürich)

  • Henrik Ravn

    (Novo-Nordisk)

Abstract

We study models for recurrent events with special emphasis on the situation where a terminal event acts as a competing risk for the recurrent events process and where there may be gaps between periods during which subjects are at risk for the recurrent event. We focus on marginal analysis of the expected number of events and show that an Aalen–Johansen type estimator proposed by Cook and Lawless is applicable in this situation. A motivating example deals with psychiatric hospital admissions where we supplement with analyses of the marginal distribution of time to the competing event and the marginal distribution of the time spent in hospital. Pseudo-observations are used for the latter purpose.

Suggested Citation

  • Per Kragh Andersen & Jules Angst & Henrik Ravn, 2019. "Modeling marginal features in studies of recurrent events in the presence of a terminal event," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(4), pages 681-695, October.
    • Handle: RePEc:spr:lifeda:v:25:y:2019:i:4:d:10.1007_s10985-019-09462-4
    DOI: 10.1007/s10985-019-09462-4
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    References listed on IDEAS

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    7. Martin Jacobsen & Torben Martinussen, 2016. "A Note on the Large Sample Properties of Estimators Based on Generalized Linear Models for Correlated Pseudo-observations," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 43(3), pages 845-862, September.
    8. Cook, Richard J. & Lawless, Jerald F. & Lakhal-Chaieb, Lajmi & Lee, Ker-Ai, 2009. "Robust Estimation of Mean Functions and Treatment Effects for Recurrent Events Under Event-Dependent Censoring and Termination: Application to Skeletal Complications in Cancer Metastatic to Bone," Journal of the American Statistical Association, American Statistical Association, vol. 104(485), pages 60-75.
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    Cited by:

    1. Julie K. Furberg & Per K. Andersen & Sofie Korn & Morten Overgaard & Henrik Ravn, 2023. "Bivariate pseudo-observations for recurrent event analysis with terminal events," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(2), pages 256-287, April.
    2. Brenière, Léa & Doyen, Laurent & Bérenguer, Christophe, 2020. "Virtual age models with time-dependent covariates: A framework for simulation, parametric inference and quality of estimation," Reliability Engineering and System Safety, Elsevier, vol. 203(C).
    3. Nießl, Alexandra & Allignol, Arthur & Beyersmann, Jan & Mueller, Carina, 2023. "Statistical inference for state occupation and transition probabilities in non-Markov multi-state models subject to both random left-truncation and right-censoring," Econometrics and Statistics, Elsevier, vol. 25(C), pages 110-124.

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