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The cost of chemotherapy administration: a systematic review and meta-analysis

Author

Listed:
  • Gursharan K. Sohi

    (Sunnybrook Research Institute)

  • Jordan Levy

    (Sunnybrook Health Sciences Centre)

  • Victoria Delibasic

    (Sunnybrook Research Institute)

  • Laura E. Davis

    (Sunnybrook Research Institute)

  • Alyson L. Mahar

    (University of Manitoba)

  • Elmira Amirazodi

    (Sunnybrook Research Institute)

  • Craig C. Earle

    (Sunnybrook Health Sciences Centre)

  • Julie Hallet

    (Sunnybrook Health Sciences Centre)

  • Ahmed Hammad

    (ICES)

  • Rajan Shah

    (Sunnybrook Research Institute)

  • Nicole Mittmann

    (Sunnybrook Health Sciences Centre)

  • Natalie G. Coburn

    (Sunnybrook Health Sciences Centre)

Abstract

Purpose Cancer treatment is a significant driver of healthcare costs worldwide, however, the economic impact of treating patients with anti-neoplastic agents is poorly elucidated. We conducted a systematic review and meta-analysis to estimate the direct costs associated with administering intravenous chemotherapy in an outpatient setting. Methods We systematically searched four databases from 2010 to present and extracted hourly administration costs and the respective components of each estimate. Separate analyses were conducted of Canadian and United States (US) studies, respectively, to address a priori hypotheses regarding heterogeneity amongst estimates. The Drummond checklist was used to assess risk-of-bias. Data were summarized using medians with interquartile ranges and five outliers were identified; costs were presented in 2019 USD. Results Forty-four studies were analyzed, including sub-analyses of 19 US and seven Canadian studies. 26/44 studies were of moderate-high quality. When components of administration cost were evaluated, physician costs were reported most frequently (24 studies), followed by lab tests (13) and overhead costs (9). The median estimate (excluding outliers) was $142/hour (IQR = $103–166). The median administration cost in the US was $149/hour (IQR = $118–158), and was $128/hour (IQR = $102–137) in Canada. Conclusions There is currently a paucity of literature addressing the costs of chemotherapy administration, and existing studies utilize a patchwork of reporting methodologies which renders direct comparison challenging. Our results demonstrate that the cost of administering chemotherapy is approximately $125–150/hour, globally. This value is dependent upon the region of analysis, inclusiveness of cost subcomponents as well as the methodology used to estimate unit prices, as described here.

Suggested Citation

  • Gursharan K. Sohi & Jordan Levy & Victoria Delibasic & Laura E. Davis & Alyson L. Mahar & Elmira Amirazodi & Craig C. Earle & Julie Hallet & Ahmed Hammad & Rajan Shah & Nicole Mittmann & Natalie G. Co, 2021. "The cost of chemotherapy administration: a systematic review and meta-analysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(4), pages 605-620, June.
  • Handle: RePEc:spr:eujhec:v:22:y:2021:i:4:d:10.1007_s10198-021-01278-0
    DOI: 10.1007/s10198-021-01278-0
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    References listed on IDEAS

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    1. Anthony T Saxton & Dan Poenaru & Doruk Ozgediz & Emmanuel A Ameh & Diana Farmer & Emily R Smith & Henry E Rice, 2016. "Economic Analysis of Children’s Surgical Care in Low- and Middle-Income Countries: A Systematic Review and Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-20, October.
    2. Katharina Schremser & Wolf Rogowski & Sigrid Adler-Reichel & Amanda Tufman & Rudolf Huber & Björn Stollenwerk, 2015. "Cost-Effectiveness of an Individualized First-Line Treatment Strategy Offering Erlotinib Based on EGFR Mutation Testing in Advanced Lung Adenocarcinoma Patients in Germany," PharmacoEconomics, Springer, vol. 33(11), pages 1215-1228, November.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    4. Hamzeh Albaba & Charles Lim & Natasha B. Leighl, 2017. "Economic Considerations in the Use of Novel Targeted Therapies for Lung Cancer: Review of Current Literature," PharmacoEconomics, Springer, vol. 35(12), pages 1195-1209, December.
    5. Philip Haywood & Johan Raad & Kees Gool & Marion Haas & Gisselle Gallego & Sallie-Anne Pearson & Margaret Faedo & Robyn Ward, 2012. "Chemotherapy Administration," PharmacoEconomics, Springer, vol. 30(12), pages 1173-1186, December.
      • Philip Haywood & Johan Raad & Kees Gool & Marion Haas & Gisselle Gallego & Sallie-Anne Pearson & Margaret Faedo & Robyn Ward, 2012. "Chemotherapy Administration," PharmacoEconomics, Springer, vol. 30(12), pages 1173-1186, December.
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