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Cost-effectiveness of precision medicine: a scoping review

Author

Listed:
  • Miriam Kasztura

    (Bern University of Applied Sciences)

  • Aude Richard

    (University of Geneva)

  • Nefti-Eboni Bempong

    (University of Geneva)

  • Dejan Loncar

    (University of Geneva)

  • Antoine Flahault

    (University of Geneva)

Abstract

Objectives Precision medicine (PM) aims to improve patient outcomes by stratifying or individualizing diagnosis and treatment decisions. Previous reviews found inconclusive evidence as to the cost-effectiveness of PM. The purpose of this scoping review was to describe current research findings on the cost-effectiveness of PM and to identify characteristics of cost-effective interventions. Methods We searched PubMed with a combination of terms related to PM and economic evaluations and included studies published between 2014 and 2017. Results A total of 83 articles were included, of which two-thirds were published in Europe and the USA. The majority of studies concluded that the PM intervention was at least cost-effective compared to usual care. However, the willingness-to-pay thresholds varied widely. Key factors influencing cost-effectiveness included the prevalence of the genetic condition in the target population, costs of genetic testing and companion treatment and the probability of complications or mortality. Conclusions This review may help inform decisions about reimbursement, research and development of PM interventions.

Suggested Citation

  • Miriam Kasztura & Aude Richard & Nefti-Eboni Bempong & Dejan Loncar & Antoine Flahault, 2019. "Cost-effectiveness of precision medicine: a scoping review," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 64(9), pages 1261-1271, December.
    • Handle: RePEc:spr:ijphth:v:64:y:2019:i:9:d:10.1007_s00038-019-01298-x
    DOI: 10.1007/s00038-019-01298-x
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