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Mimicking Clinical Trials Using Real-World Data: A Novel Method and Applications

Author

Listed:
  • Wei-Jhih Wang

    (The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, WA, USA)

  • Aasthaa Bansal

    (The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, WA, USA)

  • Caroline Savage Bennette

    (The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, WA, USA)

  • Anirban Basu

    (The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, WA, USA
    Department of Health Services, University of Washington, Seattle, WA, USA
    Department of Economics, University of Washington, Seattle, WA, USA)

Abstract

Introduction Simulating individual-level trial data when only summary data are available is often useful for meta-analysis, forming external control arms and calibrating trial results to real-world data (RWD). The joint distribution of baseline characteristics in a trial is usually simulated by combining its summary data with RWD’s correlations. However, RWD correlations may not be a perfect proxy for the trial. A misspecified correlation structure could bias any analysis in which the outcomes generating models are nonlinear or include effect modifiers. Methods We developed an iterative algorithm using copula and resampling, which was based on the estimated propensity score for the likelihood of enrollment in a trial given participants’ characteristics. Validation was performed using Monte Carlo simulations under different scenarios in which the marginal and joint distributions of covariates differ between trial samples and RWD. Two applications were illustrated using an actual trial and the Surveillance, Epidemiology, and End Results–Medicare data. We calculated the standardized mean difference (SMD) to assess the generalizability of the trial and explored the feasibility of generating an external control by applying a parametric Weibull model trained in RWD to predict survival in the simulated trial cohort. Results Across all scenarios, approximated correlations derived from the algorithm were closer to the true correlations than the RWD’s correlations. The algorithm also successfully reproduced the joint distribution of characteristics for the actual trial. A similar SMD was observed using simulated data and individual-level trial data. The 95% confidence intervals were overlapped between adjusted survival estimates from the simulated trial and actual trial Kaplan-Meier estimates. Conclusions The algorithm could be a feasible way to simulate individual-level data when only summary data are available. Further research is needed to validate our approach with larger sample sizes. Highlights The correlation structure is crucial to building the joint distribution of patient characteristics, and a misspecified correlation structure could potentially influence predicted outcomes. An iterative algorithm was developed to approximate a trial’s correlation structure using published summary trial data and real-world data. The algorithm could be a feasible way to simulate individual-level trial data when only trial summary data are available.

Suggested Citation

  • Wei-Jhih Wang & Aasthaa Bansal & Caroline Savage Bennette & Anirban Basu, 2023. "Mimicking Clinical Trials Using Real-World Data: A Novel Method and Applications," Medical Decision Making, , vol. 43(3), pages 275-287, April.
  • Handle: RePEc:sae:medema:v:43:y:2023:i:3:p:275-287
    DOI: 10.1177/0272989X221141381
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    References listed on IDEAS

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    1. Casey Quinn, 2007. "The health-economic applications of copulas: methods in applied econometric research," Health, Econometrics and Data Group (HEDG) Working Papers 07/22, HEDG, c/o Department of Economics, University of York.
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    3. Alexander J. McNeil & Rüdiger Frey & Paul Embrechts, 2015. "Quantitative Risk Management: Concepts, Techniques and Tools Revised edition," Economics Books, Princeton University Press, edition 2, number 10496.
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