IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0264953.html
   My bibliography  Save this article

A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients

Author

Listed:
  • Gabriele Rocchetti
  • Marika Vitali
  • Martina Zappaterra
  • Laura Righetti
  • Rubina Sirri
  • Luigi Lucini
  • Chiara Dall’Asta
  • Roberta Davoli
  • Gianni Galaverna

Abstract

In this work, the Longissimus thoracis pig skeletal muscle was used as a model to investigate the impact of two different diets, supplemented with n-3 polyunsaturated fatty acids from extruded linseed (L) and polyphenols from grape skin and oregano extracts (L+P), on the lipidomic profile of meat. A standard diet for growing-finishing pigs (CTRL) was used as a control. Changes in lipids profile were investigated through an untargeted lipidomics and transcriptomics combined investigation. The lipidomics identified 1507 compounds, with 195 compounds fitting with the MS/MS spectra of LipidBlast database. When compared with the CTRL group, the L+P diet significantly increased 15 glycerophospholipids and 8 sphingolipids, while the L diet determined a marked up-accumulation of glycerolipids. According to the correlations outlined between discriminant lipids and genes, the L diet may act preventing adipogenesis and the related inflammation processes, while the L+P diet promoted the expression of genes involved in lipids’ biosynthesis and adipogenic extracellular matrix formation and functioning.

Suggested Citation

  • Gabriele Rocchetti & Marika Vitali & Martina Zappaterra & Laura Righetti & Rubina Sirri & Luigi Lucini & Chiara Dall’Asta & Roberta Davoli & Gianni Galaverna, 2022. "A molecular insight into the lipid changes of pig Longissimus thoracis muscle following dietary supplementation with functional ingredients," PLOS ONE, Public Library of Science, vol. 17(3), pages 1-24, March.
    • Handle: RePEc:plo:pone00:0264953
    DOI: 10.1371/journal.pone.0264953
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0264953
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0264953&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0264953?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kandice R. Levental & Eric Malmberg & Jessica L. Symons & Yang-Yi Fan & Robert S. Chapkin & Robert Ernst & Ilya Levental, 2020. "Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    2. O'Sullivan, T.A. & Hafekost, K. & Mitrou, F. & Lawrence, D., 2013. "Food sources of saturated fat and the association with mortality: A meta-analysis," American Journal of Public Health, American Public Health Association, vol. 103(9), pages 31-42.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Laura Pimpin & Jason H Y Wu & Hila Haskelberg & Liana Del Gobbo & Dariush Mozaffarian, 2016. "Is Butter Back? A Systematic Review and Meta-Analysis of Butter Consumption and Risk of Cardiovascular Disease, Diabetes, and Total Mortality," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-18, June.
    2. Alexandre Santinho & Maxime Carpentier & Julio Lopes Sampaio & Mohyeddine Omrane & Abdou Rachid Thiam, 2024. "Giant organelle vesicles to uncover intracellular membrane mechanics and plasticity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Mina Nicole Händel & Isabel Cardoso & Katrine Marie Rasmussen & Jeanett Friis Rohde & Ramune Jacobsen & Sabrina Mai Nielsen & Robin Christensen & Berit Lilienthal Heitmann, 2019. "Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-20, October.
    4. Alfredo Erazo-Oliveras & Mónica Muñoz-Vega & Mohamed Mlih & Venkataramana Thiriveedi & Michael L. Salinas & Jaileen M. Rivera-Rodríguez & Eunjoo Kim & Rachel C. Wright & Xiaoli Wang & Kerstin K. Landr, 2023. "Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin," Nature Communications, Nature, vol. 14(1), pages 1-28, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0264953. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.