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Effects of early life adversity on immediate early gene expression: Systematic review and 3-level meta-analysis of rodent studies

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  • Heike Schuler
  • Valeria Bonapersona
  • Marian Joëls
  • R Angela Sarabdjitsingh

Abstract

Early-life adversity (ELA) causes long-lasting structural and functional changes to the brain, rendering affected individuals vulnerable to the development of psychopathologies later in life. Immediate-early genes (IEGs) provide a potential marker for the observed alterations, bridging the gap between activity-regulated transcription and long-lasting effects on brain structure and function. Several heterogeneous studies have used IEGs to identify differences in cellular activity after ELA; systematically investigating the literature is therefore crucial for comprehensive conclusions. Here, we performed a systematic review on 39 pre-clinical studies in rodents to study the effects of ELA (alteration of maternal care) on IEG expression. Females and IEGs other than cFos were investigated in only a handful of publications. We meta-analyzed publications investigating specifically cFos expression. ELA increased cFos expression after an acute stressor only if the animals (control and ELA) had experienced additional hits. At rest, ELA increased cFos expression irrespective of other life events, suggesting that ELA creates a phenotype similar to naïve, acutely stressed animals. We present a conceptual theoretical framework to interpret the unexpected results. Overall, ELA likely alters IEG expression across the brain, especially in interaction with other negative life events. The present review highlights current knowledge gaps and provides guidance to aid the design of future studies.

Suggested Citation

  • Heike Schuler & Valeria Bonapersona & Marian Joëls & R Angela Sarabdjitsingh, 2022. "Effects of early life adversity on immediate early gene expression: Systematic review and 3-level meta-analysis of rodent studies," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-21, January.
    • Handle: RePEc:plo:pone00:0253406
    DOI: 10.1371/journal.pone.0253406
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    References listed on IDEAS

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    1. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    2. Agnes Grudniewicz & David Moher & Kelly D. Cobey & Gregory L. Bryson & Samantha Cukier & Kristiann Allen & Clare Ardern & Lesley Balcom & Tiago Barros & Monica Berger & Jairo Buitrago Ciro & Lucia Cug, 2019. "Predatory journals: no definition, no defence," Nature, Nature, vol. 576(7786), pages 210-212, December.
    3. Matthew J Page & Joanne E McKenzie & Patrick M Bossuyt & Isabelle Boutron & Tammy C Hoffmann & Cynthia D Mulrow & Larissa Shamseer & Jennifer M Tetzlaff & Elie A Akl & Sue E Brennan & Roger Chou & Jul, 2021. "The PRISMA 2020 statement: An updated guideline for reporting systematic reviews," PLOS Medicine, Public Library of Science, vol. 18(3), pages 1-15, March.
    4. Ee-Lynn Yap & Noah L. Pettit & Christopher P. Davis & M. Aurel Nagy & David A. Harmin & Emily Golden & Onur Dagliyan & Cindy Lin & Stephanie Rudolph & Nikhil Sharma & Eric C. Griffith & Christopher D., 2021. "Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network," Nature, Nature, vol. 590(7844), pages 115-121, February.
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